Evidence map›Paper›PMID 41100354›Full record

ReviewRadiographics : a review publication of the Radiological Society of North America, Inc2025

Crohn Disease Strictures: Multimodality Imaging to Identify Imaging Biomarkers.

Safa Hoodeshenas, Jonathan R Dillman, Stuart A Taylor, Jordi Rimola, Bachir Taouli, Kathryn A Robinson, Aiming Lu, David J Bartlett, David H Bruining, Catherine E Hagen and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Radiographics : a review publication of the Radiological Society of North America, Inc, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. PET/MR Imaging of the Gastrointestinal Tract.Magnetic resonance imaging clinics of North America · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Safa HoodeshenasFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0001-8640-0184
Jonathan R DillmanFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0003-0124-0164
Stuart A TaylorFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).
Jordi RimolaFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0002-1814-4198
Bachir TaouliFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0001-6409-1333
Kathryn A RobinsonFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0009-0002-9753-7551
Aiming LuFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).
David J BartlettFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0002-3291-4208
David H BruiningFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0003-4320-8429
Catherine E HagenFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0002-1867-4957
Ajit H GoenkaFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0002-7804-2695
Shigao ChenFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0003-3460-127X
Florian RiederFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0002-9087-1568
Brian FeaganFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0002-6914-3822
Mark E BakerFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0001-5023-3361
Joel G FletcherFrom the Department of Radiology (S.H., K.A.R., A.L., D.J.B., A.H.G., S.C., J.G.F.), Division of Gastroenterology and Hepatology (D.H.B.), and Department of Laboratory Medicine and Pathology (C.E.H.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Center for Medical Imaging, University College London, London, UK (S.A.T.); IBD Unit, Department of Radiology, Hospital Clínic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain (J.R.); Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio (F.R.); Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Disease Research, Cleveland Clinic, Cleveland, Ohio (F.R.); Alimentiv, London, Ontario, Canada (B.F.); Department of Medicine and Department of Epidemiology and Statistics, University of Western Ontario, London, Ontario, Canada (B.F.); and Imaging Institute, Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).ORCID 0000-0002-8941-5434

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid BiopsyR01CA256969 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Collisson, Ajit Harishkumar Goenka · 2021 to 2026
$3.1M
Quantitative In Vivo 68Ga-Fibroblast-Activation-Protein-Inhibitors (FAPI)-46 PET Imaging of Cancer-Associated Fibroblasts (CAFs) in Pancreatic Ductal Adenocarcinoma (PDA)R01CA272628 · NCI · MAYO CLINIC ROCHESTER · PI GOENKA, AJIT HARISHKUMAR · 2022 to 2025
$2.5M
Septins in intestinal fibrosisR01DK132038 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Andrei Ivanovich Ivanov, Florian Rieder · 2023 to 2026
$2.5M
Creeping fat and Crohn's disease associated stricturesR01DK123233 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI RIEDER, FLORIAN · 2020 to 2024
$1.9M
Quantitative Ultrasound Imaging Biomarkers of Crohn's DiseaseR01DK120559 · NIDDK · MAYO CLINIC ROCHESTER · PI BRUINING, DAVID HENRY, CHEN, SHIGAO · 2019 to 2022
$1.7M
NCI NIH HHS P30 CA015083NCI NIH HHS R01 CA256969NCI NIH HHS R01 CA272628NIDDK NIH HHS R01 DK120559NIDDK NIH HHS R01 DK123233NIDDK NIH HHS R01 DK132038
6 · The paper itself

Abstract

The morphologic imaging features of Crohn disease (CD) small bowel strictures have been defined by intersociety recommendations and expert panels. CD small bowel strictures result in penetrating and obstructing complications that often lead to surgery. Imaging biomarkers in fibrostenosing CD can be used to reproducibly diagnose and measure strictures and identify those at high risk for subsequent surgery. Emerging biomarkers seek to accurately and reproducibly identify and measure histopathologic correlates of fibrosis, inflammation, and smooth muscle hyperplasia or hypertrophy, as well as to reflect biomechanical properties such as stiffness. The authors review and define imaging features of small bowel strictures using routine MR and CT enterography, which should be incorporated into clinical reports to guide management decisions or to use in clinical trials. The most promising quantitative imaging biomarkers reflecting histopathologic composition of small bowel strictures are reviewed with a focus on MRI and US methods. Imaging is a critical tool for the management of patients with stricturing CD.

Indexed as

Crohn DiseaseIntestinal ObstructionIntestine, SmallMultimodal ImagingBiomarkersConstriction, PathologicHumansMagnetic Resonance ImagingTomography, X-Ray ComputedUltrasonographyBiomarkers

Identifiers

PMID41100354
PMCPMC12616288

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.