Evidence map›Paper›PMID 41100170›Full record

ReviewGigaScience2025

Emerging AI approaches for cancer spatial omics.

Javad Noorbakhsh, Ali Foroughi Pour, Jeffrey Chuang

Abstract readReview
In one paragraph

Review in GigaScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  7. Integrating multi-omics data for next-generation cancer research and precision medicine.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  8. Review
  9. Article
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  11. From spatial maps to therapeutic targets: Next challenge for artificial intelligence in cancer spatial omics.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026
    Article
  12. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Javad NoorbakhshThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0002-6196-8061
Ali Foroughi PourSt Jude Children's Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-3547-0796
Jeffrey ChuangThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.ORCID 0000-0002-3298-2358

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
The KAPP-Sen Tissue Mapping Center CollaborativeU54AG075941 · NIA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI GAROVIC, VESNA D, KUCHEL, GEORGE A · 2021 to 2025
$13.8M
Quantitative Computational Methods to Accurately Measure Tumor Heterogeneity in Solid Tumors to Inform Development of Evolution-based Treatment StrategiesR01CA230031 · NCI · JACKSON LABORATORY · PI CHUANG, JEFFREY HSU-MIN · 2018 to 2022
$2.6M
Jackson Laboratory Cancer Center's Cancer Advanced TechnologyNCI NIH HHS P30 CA034196NCI NIH HHS R01 CA230031NIA NIH HHS U54 AG075941
6 · The paper itself

Abstract

Technological breakthroughs in spatial omics and artificial intelligence (AI) have the potential to transform the understanding of cancer cells and the tumor microenvironment. Here we review the role of AI in spatial omics, discussing the current state-of-the-art and further needs to decipher cancer biology from large-scale spatial tissue data. An overarching challenge is the development of interpretable spatial AI models, an activity that demands not only improved data integration but also new conceptual frameworks. We discuss emerging paradigms-in particular, data-driven spatial AI, constraint-based spatial AI, and mechanistic spatial modeling-as well as the importance of integrating AI with hypothesis-driven strategies and model systems to realize the value of cancer spatial information.

Indexed as

Artificial IntelligenceComputational BiologyGenomicsNeoplasmsHumansTumor Microenvironmentartificial intelligencedeep learningfoundation modelsspatial proteomicsspatial transcriptomicstissue biophysics

Identifiers

PMID41100170
PMCPMC12612624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.