ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2026
Plasmacytoid dendritic cells modulate the production of mucosal IgA in IgA nephropathy.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Bovine Lactoferrin Modulates Mononuclear Cell Activity in Human Palatine Tonsils.International journal of molecular sciences · 2026Article
- TLR7/9-mediated mucosal innate immune dysregulation in IgA nephropathy.Frontiers in immunology · 2026Review
- Gut-kidney axis in IgA nephropathy: mechanisms linking microbiota dysbiosis to immune dysregulation, Gd-IgA1 generation, and renal injury.Frontiers in immunology · 2026Review
- The role of mucosal immune dysregulation in the pathogenesis of immunoglobulin A nephropathy.Frontiers in immunology · 2026Review
- Toll-like receptors and their role in the pathogenesis of myasthenia gravis: a comprehensive review.Frontiers in immunology · 2025Review
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10 authors.
Funding
Abstract
background and hypothesisAberrantly glycosylated immunoglobulin A (IgA) plays a central role in the pathogenesis of IgA nephropathy (IgAN). The activation of Toll-like receptor 9 (TLR9) has been shown to induce aberrant glycosylation of IgA via the a proliferation-inducing ligand (APRIL)-mediated pathway. TLR9 is known to be highly expressed in B cells and plasmacytoid dendritic cells (pDCs). Although the stimulation of TLR9 in B cells has been reported to promote the production of aberrantly glycosylated IgA, the effects of TLR9 stimulation on pDCs remain unclear. Therefore, in this study, we focused on the role of mucosal pDCs in the synthesis of aberrantly glycosylated IgA in patients with IgAN.
methodsWe evaluated the distribution of the DC subsets in tonsillar mononuclear cells (MNCs). The synthesis of aberrantly glycosylated IgA in MNCs cultured with or without pDCs was analyzed. We also evaluated the effects of pDC depletion on the production of aberrantly glycosylated IgA in ddY mice, a spontaneous murine model of IgAN, nasally immunized with CpG-oligonucleotide, a ligand for TLR9.
resultsThe percentage of DCs, especially pDCs, was significantly higher in the palatine tonsils of patients with IgAN than in those of patients with chronic tonsillitis. In patients with IgAN, the abundance of pDCs was significantly correlated with the APRIL and TLR9 expressions in tonsillar MNCs. The levels of aberrantly glycosylated IgA in culture supernatants of tonsillar MNCs were found to be increased in the presence of pDCs. The pDC-depleted ddY mice exhibited significantly lower serum levels of aberrantly glycosylated IgA in vivo.
conclusionMucosal pDCs contribute to the pathogenesis of IgAN by facilitating the production of aberrantly glycosylated IgA via TLR9 signaling. Our findings demonstrated that pDC may be a novel therapeutic target for IgAN.
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