Evidence map›Paper›PMID 41100054›Full record

ArticleThe American journal of bioethics : AJOB2026

Reflections on a Principal of Research Ethics: Tom Beauchamp, Moral Specification, and Waivers of Informed Consent.

Stephanie Morain, Luke Gelinas, David Wendler, P Pearl O'Rourke, Emily Largent

Abstract readHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of bioethics : AJOB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Stephanie MorainBerman Institute of Bioethics.ORCID 0000-0001-7278-7517
Luke GelinasAdvarra IRB.ORCID 0000-0002-6277-148X
David WendlerNIH Clinical Center.
P Pearl O'RourkeRetired.
Emily LargentUniversity of Pennsylvania.

Funding

NIH Health Care Systems Research Collaboratory-Coordinating Center (U24)U24AT009676 · NCCIH · DUKE UNIVERSITY · PI LESLEY H CURTIS, Adrian Hernandez · 2017 to 2026
$21.5M
Research and clinical care without informed consentZIACL010537 · CLC · CLINICAL CENTER · PI WENDLER, DAVID S · 2014 to 2025
$0k
Intramural NIH HHS ZIA CL010537NCCIH NIH HHS U24 AT009676
6 · The paper itself

Abstract

Tom Beauchamp's work is deeply woven into the field of bioethics. In this article, we honor Professor Beauchamp's pioneering contributions to research ethics, focusing on his seminal work articulating the key ethical principles that have become central to our understanding of research ethics scholarship and practice. We then examine how Professor Beauchamp's analytical framework of shared moral principles for research ethics can inform a contemporary ethics challenge: when can the requirements of informed consent permissibly be relaxed for research studies embedded into clinical care? We use this example both to illustrate how conceptual analysis and moral specification can inform the work of investigators, institutional review boards, and others charged with ensuring the ethical conduct of human subjects research, and to highlight where further conceptual work and practical guidance are needed.

Indexed as

Ethics, ResearchHuman ExperimentationInformed ConsentMoralsEthics Committees, ResearchHistory, 20th CenturyHistory, 21st CenturyHumansResearch SubjectsUnited Statesclinical trialscomparative effectiveness researchinformed consentpragmatic clinical trialsResearch ethics

Identifiers

PMID41100054
PMCPMC12614633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.