ArticleAnnals of biomedical engineering2025
Mechanical Characterisation of Grey, White, and Interface Behaviour in the Brain.
Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTraumatic brain injury is a significant healthcare burden, mild traumatic brain injuries such as concussions comprising most of these, despite rampant underdiagnosis. While evidence shows repeat concussions are a risk factor for aggressive neurodegeneration, the mechanism by which concussions damage the brain is not well understood, with the clinical hypothesis of shear delamination at the grey/white matter interface being challenging to validate using current scanning technology.
methodsThirty-five fresh ovine brains were dissected, generating ~ 950 samples for testing. Samples of grey and white matter were subjected to unconfined compression and tension, simple shear, tensile and shear fracture, and stress relaxation, load rate variation, and volumetric analysis in compression and tension. Samples at the grey/white interface were subjected to tensile and shear fracture.
resultsGrey and white matter differ between cortex/corona radiata and deep brain/corpus callosum, with additional corona radiata variance in shear. The stress relaxation magnitude of grey matter is not strain rate dependent long term; however, white matter relaxation is. Grey and white matter show asymmetric compressibility, with more volume change in tension than in compression. Fracture is not limited to grey/white interface in tension or shear, also occurring in bulk grey and white matter. Fracture initiation stress is similar between grey and white in both modes, and is lower at the interface, with the ductility variance between tissues reflected in fracture energy.
conclusionRegional variance in constitutive behaviour was uncovered, in addition to novel viscoelastic, volumetric, and fracture behaviour, which has significant implications for in vitro/in silico brain models.
Indexed as
Identifiers
41100047What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.