Evidence map›Paper›PMID 41100022›Full record

ArticleActa parasitologica2025

In Vitro Action of Papaya (Carica Papaya) Latex and Pure Papain Against Eimeria Bovis Oocysts.

Lucas Nogueira de Siqueira, Débora Castro Toledo de Souza, Ruth Celestina Condori Mamani, Lisseth Bibiana Puentes Figueroa, Laísa Bastos Albuquerque, Tiago Facury Moreira, Fabio Ribeiro Braga, Filippe Elias de Freitas Soares

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Article in Acta parasitologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Enzymatic Degradation ofMolecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucas Nogueira de SiqueiraLaboratory of Biotechnology and Applied Biochemistry, Department of Chemistry, Federal University of Lavras, Lavras, Brazil.
Débora Castro Toledo de SouzaLaboratory of Biotechnology and Applied Biochemistry, Department of Chemistry, Federal University of Lavras, Lavras, Brazil.
Ruth Celestina Condori MamaniLaboratory of Biotechnology and Applied Biochemistry, Department of Chemistry, Federal University of Lavras, Lavras, Brazil.
Lisseth Bibiana Puentes FigueroaLaboratory of Biotechnology and Applied Biochemistry, Department of Chemistry, Federal University of Lavras, Lavras, Brazil.
Laísa Bastos AlbuquerqueDepartment of Veterinary Clinic and Surgery, School of Veterinary Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Tiago Facury MoreiraDepartment of Veterinary Clinic and Surgery, School of Veterinary Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Fabio Ribeiro BragaLaboratory of Experimental Parasitology and Biological Control, Vila Velha University, Vila Velha, Brazil.
Filippe Elias de Freitas SoaresLaboratory of Biotechnology and Applied Biochemistry, Department of Chemistry, Federal University of Lavras, Lavras, Brazil. filippe.soares@ufla.br.

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-02466-21
6 · The paper itself

Abstract

purposeEimeria bovis is a protozoan disease-causing coccidiosis, a which affects significantly on the global cattle industry. Nonetheless, the control measures implemented have not been entirely effective, thus prompting the search for alternative methods for the parasitic and/or environmental control of the infecting forms (sporulated oocysts). The study aimed to evaluate the effect of papaya (Carica papaya) latex and pure papain on both sporulated and non-sporulated E. bovis oocysts.

methodsOocysts were collected from the feces of calves previously inoculated with E. bovis and stored in a potassium dichromate solution. Subsequently, the oocysts were assessed for the application of aqueous solutions (both active and denatured) of latex and papain at concentrations of 10%, 15%, and 30% (w/v), alongside a control group (water), which were incubated at 28 °C for 48 h. A reduction in oocyst counts was observed in the treatments compared to the control group.

resultsHowever, a significant difference (p < 0.01) was noted only at the concentration of 30% papain (m/v) in relation to the control.

conclusionThe findings suggest that extracts of C. papaya, rich in papain, hold considerable potential for future applications in the control of E. bovis.

Indexed as

CaricaEimeriaLatexOocystsPapainAnimalsCattleCattle DiseasesCoccidiosisFecesLatexPapainBiopesticideCarica PapayaEimeria BovisLatexPapain

Identifiers

PMID41100022

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.