ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Associations of child and adolescent obesity with the risk of neuroinflammatory diseases: analysis of data from a global health-care database.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Obesity, Nutrition and the Multiple Sclerosis Risk in Adolescents.Brain sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionThe prevalence of child and adolescent obesity has increased globally. Research has associated obesity-induced immune dysregulation with neurological autoimmune diseases. This study investigated whether obesity-driven inflammation and immunomodulation increase the risk of neuroinflammatory diseases in children and adolescents.
methodsThis retrospective cohort study collected deidentified data from individuals aged 6-18 years from the TriNetX platform. The study cohort was stratified by body mass index (BMI). The outcome measure was the incidence of neuroinflammatory diseases. Covariate-adjusted cox proportional-hazards models were used to assess neuroinflammatory disease risk across the BMI groups.
resultsChildren and adolescents with obesity (BMI: 85th-95th percentile range) and those with severe obesity (BMI: 95th-100th percentile range) had 1.76- and 1.90-fold higher risks of multiple sclerosis (MS), respectively, than did their normal-weight peers. Subgroup analysis revealed that girls and adolescents (age: 12-18 years) were particularly susceptible to MS. The risk of acute disseminated demyelination was elevated in children with obesity but not in those with severe obesity. Notably, no significant association was observed between obesity and myasthenia gravis, inflammatory polyneuropathy, or inflammatory myositis.
conclusionOur findings associate child and adolescent obesity with MS; the associations are likely mediated by systemic inflammation and immune dysregulation. The absence of significant associations between child and adolescent obesity and other neuroinflammatory diseases suggests disease-specific mechanisms, underscoring the need for targeted interventions to mitigate the neurological effects of obesity. Overall, child and adolescent obesity significantly modulate immune function, increasing the risk of certain autoimmune neurological diseases, particularly MS. Early interventions are crucial for reducing long-term health risks.
Indexed as
Identifiers
41100007What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.