Evidence map›Paper›PMID 41099975›Full record

ArticleJournal of patient-reported outcomes2025

Does the relationship between stress and quality of life differ among informal caregivers of older adults with Alzheimer's disease and children with autism spectrum disorder? Results from a cross-sectional survey.

Nilesh Gangan, Meagan Rosenthal, Arman Arabshomali, Erin Holmes, Benjamin F Banahan, Ruchit Shah, John P Bentley

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Article in Journal of patient-reported outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nilesh GanganCarelon Research, Wilmington, DE, USA. nileshgangan@gmail.com.ORCID http://orcid.org/0000-0001-6581-7239
Meagan RosenthalDepartment of Pharmacy Administration, University of Mississippi School of Pharmacy, University, MS, USA.
Arman ArabshomaliDepartment of Pharmacy Administration, University of Mississippi School of Pharmacy, University, MS, USA.
Erin HolmesDepartment of Pharmacy Administration, University of Mississippi School of Pharmacy, University, MS, USA.
Benjamin F BanahanDepartment of Pharmacy Administration, University of Mississippi School of Pharmacy, University, MS, USA.
Ruchit ShahDaiichi Sankyo, Basking Ridge, NJ, USA.
John P BentleyDepartment of Pharmacy Administration, University of Mississippi School of Pharmacy, University, MS, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInformal caregiving may impact the physical, mental and economic well-being and ultimately the quality of life (QOL) of the caregivers, however, each caregiver may differ in the degree to which their QOL is impacted. Little is known about association of stressors and coping mechanism in subjective variation of QOL among informal caregivers. This study aimed to understand the appraisal process for QOL among informal caregivers and compare informal caregivers of older adults and children with respect to their appraisal of QOL. METHODOLOGY: This cross-sectional study utilized a web-based survey to gather data from two distinct groups of informal caregivers: those caring for older adults with Alzheimer’s Disease (AD) and those caring for children with Autism Spectrum Disorder (ASD). Caregivers at least 18 years of age were administered a survey that included previously-developed scales to measure stress, coping mechanism, and QOL. Structural equation modeling was employed to assess the mediating role of coping behaviors in the relationship between perceived stress and QOL and multiple-group analysis was performed to evaluate differences between the caregiver groups.

resultsOf the 417 included caregivers, 210 (50.4%) were AD patient caregivers and 207 (49.6%) were ASD patient caregivers. In model testing, perceived stress was negatively associated with global QOL for both groups (i.e. direct effects) (estimate = −0.637, 95% CI: −0.777 to −0.529 for the ASD caregiver group; estimate = −0.601, 95% CI: −0.731 to −0.468 for the AD caregiver group). The only statistically significant indirect effect was perceived stress on global QOL through dysfunctional coping for the AD caregivers (estimate = −0.026, 95% CI: −0.048 to −0.005). None of the differences in indirect and direct effects between the two caregiver groups were statistically significant.

conclusionsPerceived stress was significantly associated with QOL among informal caregivers, irrespective of the condition of the patient cared for, be it AD or ASD. Dysfunctional coping strategies played a significant role in mediating this relationship only among AD caregivers. However, the two caregiver groups did not differ between them in appraisal of QOL. Stress management among caregivers will aid in their ability to have a good QOL.

Indexed as

Alzheimer DiseaseAutism Spectrum DisorderCaregiversQuality of LifeStress, PsychologicalAdaptation, PsychologicalAdultAgedChildCoping SkillsCross-Sectional StudiesFemaleHumansMaleMiddle AgedSurveys and QuestionnairesAlzheimer’s diseaseAustism spectrum disorderCaregiver-reported outcomesInformal caregiverQuality of lifeStressStructural equation modeling

Identifiers

PMID41099975
PMCPMC12532540

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.