ArticleMetabolic brain disease2025
Synbiotic laden with Faecalibacterium prausnitzii, fructooligosaccharides, and galactooligosaccharides mitigates quinpirole-induced OCD-like symptoms in rats.
Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Obsessive-compulsive disorder (OCD) is a mental illness of unwanted recurrent thoughts and compulsive behaviors. The significance of the microbiota-gut-brain axis has been increasingly documented in the manifestation of neuropsychiatric disorders. Herein, we investigated the impact of synbiotic containing Faecalibacterium prausnitzii ATCC 27,766 (F. prausnitzii) and prebiotics [fructooligosaccharides (FOS) and galactooligosaccharides (GOS)] on quinpirole-induced OCD-like symptoms in rats. Repeated quinpirole injections led to compulsive- and anxiety-like behaviors, as rats showed reduced head-dipping behavior in the hole board test, increased marble burying and self-grooming behaviors, and decreased exploration of open areas during elevated plus maze testing. Treatment with Faecalibacterium prausnitzii combined with prebiotics (FOS and GOS) over a six-week period improved these behavioral alterations, reducing signs of repetitive, compulsive, and anxiety-related behaviors. Notably, neither open-field locomotion nor body weight showed significant differences between the experimental groups. In molecular studies, synbiotic treatment showed a reversal of elevated levels/mRNA expression of TNF-α and IL-6 in the frontal cortex and increased mRNA expression of tryptophan hydroxylase (TPH-1) in the colon of quinpirole-injected rats. The cohorts of rats received synbiotic treatment showed normalization of intestinal parameters, including fecal short-chain fatty acid concentrations (acetate, propionate, and butyrate), as well as improvements in intestinal morphology markers such as villi-crypt ratios, goblet cell populations, occludin and TPH1 expression in the colon. These findings highlight the potential benefits of synbiotic laden with F. prausnitzii and prebiotics (FOS + GOS) in alleviating quinpirole-induced OCD-like symptoms by reshaping animal gut-brain-axis mediators.
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