Evidence map›Paper›PMID 41099943›Full record

ArticlePituitary2025

Exercise ventilatory inefficiency may be a specific feature of patients with acromegaly.

Gianluigi Dorelli, Massimo Venturelli, Giulia Sartori, Alberto Fantin, Mattia Cominacini, Michele Braggio, Luca Dalle Carbonare, Elia Piccinno, Maria Vittoria Davì, Federico Schena and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Acromegaly complications: an update.The Journal of clinical endocrinology and metabolism · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gianluigi DorelliDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-9004-7587
Massimo VenturelliDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-2469-8787
Giulia SartoriRespiratory Medicine Unit, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Largo L.A. Scuro, 10, Verona, 37134, Italy.ORCID http://orcid.org/0000-0003-1283-4718
Alberto FantinRespiratory Medicine Unit, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Largo L.A. Scuro, 10, Verona, 37134, Italy.ORCID http://orcid.org/0000-0002-5707-775X
Mattia CominaciniDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-4315-0282
Michele BraggioDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0001-7163-6194
Luca Dalle CarbonareDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0003-3263-6671
Elia PiccinnoDepartment of Emergency Medicine, Integrated University Hospital of Verona, Verona, Italy.
Maria Vittoria DavìEndocrine Unit, Pederzoli Hospital, Peschiera del Garda (Verona), Italy.
Federico SchenaDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Ernesto CrisafulliRespiratory Medicine Unit, Department of Medicine, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Largo L.A. Scuro, 10, Verona, 37134, Italy. ernesto.crisafulli@univr.it.ORCID http://orcid.org/0000-0001-7298-7084

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeReduction in exercise capacity and peak oxygen uptake (V̇O

methodsWe prospectively evaluated 10 patients with acromegaly in a phase of disease control. To minimise confounders related to ventilatory response and anthropometric differences, acromegalic patients were matched with 10 control subjects according to age, body mass index, and body surface area. Chronic diseases, any cardio-respiratory condition likely to alter ventilatory response, and evidence of cardiac dysfunction were excluded. Pulmonary function tests and maximal cardiopulmonary exercise testing were performed. Ventilatory response was assessed via minute ventilation (V̇

resultsNo alterations in lung function were observed in either group. Compared with controls, patients with acromegaly showed lower power output and V̇O

conclusionPatients with acromegaly display ventilatory inefficiency during exercise. These findings suggest subclinical alveolar-capillary impairment or altered CO

Indexed as

AcromegalyExercisePulmonary VentilationAdultExercise TestFemaleHumansMaleMiddle AgedOxygen ConsumptionProspective StudiesRespiratory Function TestsAcromegalyCardiopulmonary exercise testingGrowth hormoneVentilatory inefficiency

Identifiers

PMID41099943
PMCPMC12532638

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.