Evidence map›Paper›PMID 41099917›Full record

ArticleAnnals of intensive care2025

Incidence and outcomes of extubation failure in mechanically ventilated patients with cirrhosis: a post-hoc analysis of a prospective multicenter study.

Yassir Aarab, Joris Pensier, Fanny Garnier, Clement Monet, Ines Lakbar, Gerald Chanques, Audrey de Jong, Mathieu Capdevila, Samir Jaber, FreeRéa study group

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02450669 (Practices and Risk Factors for Weaning and Extubation Airway Failure in Adult Intensive Care Unit), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02450669 completednot on this map

Practices and Risk Factors for Weaning and Extubation Airway Failure in Adult Intensive Care Unit: a Multicenter Trial

TypeobservationalSponsorUniversity Hospital, MontpellierRan2013 to 2015Enrolled417ConditionsIntubation in Intensive Care Units
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yassir Aarab *Anesthesiology and Intensive Care Unit, Anesthesia and Critical Care Department B, INSERM U1046, CNRS UMR 9214, Saint Eloi Teaching Hospital, PhyMedExp, University of Montpellier, 80 Avenue Augustin Fliche, 34295, Montpellier, Cedex 5, France.
Joris Pensier *Anesthesiology and Intensive Care Unit, Anesthesia and Critical Care Department B, INSERM U1046, CNRS UMR 9214, Saint Eloi Teaching Hospital, PhyMedExp, University of Montpellier, 80 Avenue Augustin Fliche, 34295, Montpellier, Cedex 5, France.
Fanny GarnierIntensive Care Unit, Clinique Saint-Jean Sud de France, Montpellier, France.
Clement MonetAnesthesiology and Intensive Care Unit, Anesthesia and Critical Care Department B, INSERM U1046, CNRS UMR 9214, Saint Eloi Teaching Hospital, PhyMedExp, University of Montpellier, 80 Avenue Augustin Fliche, 34295, Montpellier, Cedex 5, France.
Ines LakbarAnesthesiology and Intensive Care Unit, Anesthesia and Critical Care Department B, INSERM U1046, CNRS UMR 9214, Saint Eloi Teaching Hospital, PhyMedExp, University of Montpellier, 80 Avenue Augustin Fliche, 34295, Montpellier, Cedex 5, France.
Gerald ChanquesAnesthesiology and Intensive Care Unit, Anesthesia and Critical Care Department B, INSERM U1046, CNRS UMR 9214, Saint Eloi Teaching Hospital, PhyMedExp, University of Montpellier, 80 Avenue Augustin Fliche, 34295, Montpellier, Cedex 5, France.
Audrey de JongAnesthesiology and Intensive Care Unit, Anesthesia and Critical Care Department B, INSERM U1046, CNRS UMR 9214, Saint Eloi Teaching Hospital, PhyMedExp, University of Montpellier, 80 Avenue Augustin Fliche, 34295, Montpellier, Cedex 5, France.
Mathieu Capdevila *Anesthesiology and Intensive Care Unit, Anesthesia and Critical Care Department B, INSERM U1046, CNRS UMR 9214, Saint Eloi Teaching Hospital, PhyMedExp, University of Montpellier, 80 Avenue Augustin Fliche, 34295, Montpellier, Cedex 5, France.
Samir Jaber *Anesthesiology and Intensive Care Unit, Anesthesia and Critical Care Department B, INSERM U1046, CNRS UMR 9214, Saint Eloi Teaching Hospital, PhyMedExp, University of Montpellier, 80 Avenue Augustin Fliche, 34295, Montpellier, Cedex 5, France. s-jaber@chu-montpellier.fr.ORCID http://orcid.org/0000-0002-7257-8069
FreeRéa study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with comorbidities who are liberated from invasive mechanical ventilation could be at risk of extubation failure in the intensive care unit (ICU). Incidence and associated outcomes of reintubation in patients with cirrhosis have been poorly studied. We aimed to evaluate the incidence, causes and mortality of reintubation in patients with cirrhosis.

methodsWe conducted a post hoc analysis of the French prospective multicenter observational trial (FREE-REA) evaluating the incidence and risk factors of extubation failure in 26 ICUs. The primary outcome was the incidence of extubation failure defined as the need for reintubation within 7 days after extubation. Secondary outcomes were the incidence of reintubation at 48 h, the causes and risk factors of extubation failure, ICU length of stay and in-hospital mortality. We compared patients with cirrhosis and patients without cirrhosis.

resultsOf the 1,443 analyzed patients, 165 (11%) had cirrhosis. The incidence of reintubation within 7 days was 21% (34/165) in patients with cirrhosis and 13% (167/1278) in patients without cirrhosis (p < 0.01). Reintubation at 48 h was not significantly different between patients with cirrhosis and patients without cirrhosis (9% versus 10%, p = 0.55). Admission for shock was identified as the only independent risk factor for extubation failure in multivariate analysis [OR 3.24, 95% CI (1.24-8.44), p = 0.02]. In patients with extubation failure, ICU length of stay was significantly longer in patients with cirrhosis compared to those without (28 ± 25 versus 18 ± 12 days, p < 0.01); In-hospital mortality was higher in extubation failure patients with cirrhosis in comparison to patients without cirrhosis without reaching significance (16/34 (47%) versus 51/167 (31%), p = 0.06).

conclusionExtubation failure was significantly higher in patients with cirrhosis compared to patients without cirrhosis. A trend for higher in-hospital mortality was observed in reintubatedpatients with cirrhosis. Neurologic failure was the main cause for reintubation at 48 h in patients with cirrhosis. CLINICAL TRIALS: The study was registered on clinicaltrials.gov (identifier no. NCT02450669). Registered 01/12/2013.

Indexed as

CirrhosisExtubation failureIntensive care unitMechanical ventilation

Identifiers

PMID41099917
PMCPMC12532547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.