ReviewHerz2025
The extravascular implantable cardioverter-defibrillator: technology, evidence, and clinical perspectives.
Review in Herz, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extravascular implantable cardioverter-defibrillator (EV-ICD) offers a fully extravascular alternative to transvenous ICDs, combining substernal lead placement with defibrillation and limited pacing capabilities. Designed to mitigate intravascular complications while maintaining generator size and longevity comparable to conventional ICDs, the EV-ICD supports antitachycardia pacing, post-shock pacing, and temporary bradycardia management. Procedural experience demonstrates high implantation success, low rates of major complications, and effective arrhythmia termination. Early real-world data indicate that lead dislodgement, pneumothorax, and pocket infection are uncommon, and lead explantation is feasible when required. Antitachycardia pacing effectively terminates a substantial proportion of ventricular tachycardias, while inappropriate therapies have been reduced through optimized lead positioning and advanced detection algorithms. Patient selection should exclude, among others, those with permanent pacing needs, anatomical constraints, and prior radiotherapy or sternotomy. Future directions include optimization of lead design and exploration of alternative implantation sites, with ongoing evaluation of long-term device performance and safety. Current evidence supports the EV-ICD as a safe and effective option in selected patients, including younger populations or those with limited vascular access, although its definitive role in sudden cardiac death prevention requires further long-term study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.