Evidence map›Paper›PMID 41099806›Full record

ArticleEuropean biophysics journal : EBJ2026

DNA methylation enhances cooperative disentanglement by the Hfq nucleoid-associated protein.

Frank Wien, Nykola C Jones, Søren Vrønning Hoffmann, Véronique Arluison

Abstract read
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In one paragraph

Article in European biophysics journal : EBJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Frank WienSynchrotron SOLEIL, L'Orme Des Merisiers, Départementale 128, 91190, Saint Aubin, France.ORCID http://orcid.org/0000-0002-0752-8735
Nykola C JonesISA, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000, Aarhus C, Denmark.ORCID http://orcid.org/0000-0002-4081-6405
Søren Vrønning HoffmannISA, Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, 8000, Aarhus C, Denmark.ORCID http://orcid.org/0000-0002-8018-5433
Véronique ArluisonSynchrotron SOLEIL, L'Orme Des Merisiers, Départementale 128, 91190, Saint Aubin, France. veronique.arluison@u-paris.fr.ORCID http://orcid.org/0000-0003-4056-7282

Funding

MOSBRI MOSBRI-2022-129)
6 · The paper itself

Abstract

The Hfq protein is not only a mediator of RNA metabolism but also a key structural element involved in nucleic acid shaping. Its ability to compact and organize DNA, as well as its influence on the dynamics of various DNA-related processes, makes Hfq a central player in the regulation of bacterial chromosomal architecture and function. We previously demonstrated that different DNA methylation states affect Hfq binding and mobility. In this study, we show that Hfq, through its C-terminal region, can influence a DNA entangled/disentangled transition and examine the impact of DNA methylation on this previously uncharacterized function of Hfq. This discovery provides new insights into the role of Hfq in DNA transactions, with potential implications for essential cellular processes such as recombination and replication. Furthermore, this study demonstrates that Synchrotron Radiation Linear Dichroism (SRLD) is a powerful tool that can follow cooperative vs non-cooperative protein induced DNA structural transitions.

Indexed as

DNA MethylationEscherichia coli ProteinsHost Factor 1 ProteinEscherichia coliNucleic Acid ConformationEscherichia coli ProteinsHfq protein, E coliHost Factor 1 ProteinBacterial chromatinDNA entanglementsDNA methylationFunctional amyloidNucleoid associated protein (NAP)RNA chaperoneSynchrotron Radiation Linear and Circular Dichroism (SRLD/CD)

Identifiers

PMID41099806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.