Evidence map›Paper›PMID 41099634›Full record

ArticleHepatic oncology2025

Two-way increased-risk associations between hepatobiliary cancers and other malignancies: a population-based study.

Huibiao Deng, Xiaoyuan Gong, Meiling Wang, Qingqing Zhang, Fei Li, Xiaohong Wu, Qidi Zhang

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Article in Hepatic oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Huibiao DengDepartment of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoyuan GongDepartment of Endoscopy Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Meiling WangDepartment of Gastroenterology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai.
Qingqing ZhangDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fei LiDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaohong WuDepartment of Outpatient Department, Shanghai University of International Business and Economics, Shanghai, China.
Qidi ZhangDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimOur aim was to examine two-way increased-risk associations between hepatobiliary cancers and malignancies that develop before/after them. PATIENTS AND

methodsData of USA from Surveillance, Epidemiology, and End Results (SEER), 17 registries (2000-2021) were analyzed using different statistical methods.

resultsOverall, 5,574,604 cancer cases were identified, which included hepatocellular carcinoma (HCC) (59,764), cancer of bile duct (including Ampulla of Vater) (22,735), cancer of gallbladder (10,155), and other malignancies (5,481,950). We found two-way increased-risk associations for the following eight cancer pairs: HCC-upper aerodigestive tract, HCC-esophagus, HCC-stomach, HCC-anus, HCC-bile duct, HCC-lung/bronchus, HCC-non-Hodgkin lymphoma, and bile duct-stomach. After HCC or bile duct cancer, the standardized incidence ratios (SIRs) (95% CI) of the corresponding second primary malignancies (SPMs) were 1.88 (1.61-2.18), 1.46 (1.07-1.96), 1.59 (1.25-2.00), 3.53 (2.31-5.18), 3.98 (3.15-4.97), 1.54 (1.41-1.69), 2.2 (1.92-2.52), and 2.30 (1.59-3.21), respectively. In reverse order (i.e. HCC or bile duct cancer as SPM), the SIRs (95% CI) were 1.48 (1.34-1.62), 1.43 (1.06-1.90), 1.49 (1.22-1.79), 1.76 (1.27-2.36), 1.62 (1.03-2.44), 1.39 (1.27-1.53), 1.31 (1.19-1.44), and 1.73 (1.31-2.24), respectively.

conclusionThe major shared etiologic factors for the identified cancer pairs were life-style (smoking, alcohol use, and excess body weight), chronic infections (hepatitis B and C viruses), and genetic risks.

Indexed as

bile duct cancergallbladder cancerhepatocellular carcinomaSecond primary malignancyshared etiologic factors

Identifiers

PMID41099634
PMCPMC12536636

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