ArticleNucleic acids research2026
PMADS: an integrated database of curated and proteomics-inferred associations between protein post-translational modifications and drug sensitivity.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The 2026 Nucleic Acids Research database issue and the online molecular biology database collection.Nucleic acids research · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Post-translational modifications (PTMs) are critical regulators of protein stability, localization, and function and have been increasingly implicated in shaping drug responses across diverse diseases. While numerous studies have reported PTM-related mechanisms of drug sensitivity or resistance, no resource has systematically catalogued these associations in disease-specific contexts. Here, we present protein modification and drug sensitivity (PMADS), an integrated database that systematically organizes PTM-drug-disease ternary associations, defined as PTM-centered drug responses in disease context. PMADS catalogues over 4700 curated associations manually extracted from biomedical literature and over 43 800 predicted associations derived from analysis of large-scale proteomics datasets. Together, PMADS covers >6000 proteins, 1000 drugs, 19 types of PTMs, and 300 disease classes. The database emphasizes both upstream regulatory mechanisms, such as drug-induced modulation of PTMs, and downstream effects, such as PTM-mediated changes in drug sensitivity. Each entry includes detailed annotations such as PTM site, effect description, ternary diagram, supporting evidence, confidence score, and cross-references to external databases, including PDB, PhosphoSitePlus, and DrugBank. PMADS features a user-friendly web interface with advanced search, interactive visualizations, and structured data export to support research in pharmacology, functional genomics, and precision medicine. PMADS is freely available at https://pmads-db.org.
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Registered trials
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