Evidence map›Paper›PMID 41099505›Full record

Observational studymSystems2025

Bladder health and the urogenital microbiome in community-dwelling adult females.

L Brubaker, D McDonald, S Putnam, C Brennan, C S Fok, C E Lewis, J L Lowder, M G Mueller, L M Rickey, E R Mueller and 5 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

L BrubakerDepartment of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-8598-2589
D McDonaldDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
S PutnamSchool of Public Health, Division of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, Minnesota, USA.
C BrennanDivision of Biological Sciences, University of California San Diego, La Jolla, California, USA.ORCID 0000-0003-3943-6701
C S FokDepartment of Urology, University of Minnesota, Minneapolis, Minnesota, USA.
C E LewisDepartment of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
J L LowderDepartment of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
M G MuellerDepartment of Obstetrics and Gynecology, University of Chicago, Pritzker School of Medicine, Chicago, Illinois, USA.
L M RickeyDepartment of Urology, Yale University School of Medicine, New Haven, Connecticut, USA.
E R MuellerDepartment of Obstetrics and Gynecology, Loyola University Chicago Stritch School of Medicine, Chicago, Illinois, USA.
S J SongCenter for Microbiome Innovation, Jacobs School of Engineering, University of California San Diego, La Jolla, California, USA.
K RudserSchool of Public Health, Division of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, Minnesota, USA.
R KnightDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-0975-9019
E S LukaczDepartment of Obstetrics, Gynecology, and Reproductive Sciences, UC San Diego School of Medicine, University of California San Diego, La Jolla, California, USA.
PLUS Consortium

Funding

Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Scientific and Data Coordinating CenterU24DK106786 · NIDDK · UNIVERSITY OF MINNESOTA · PI MCGWIN, GERALD, RUDSER, KYLE · 2020 to 2024
$7.1M
University of Pennsylvania+ PLUS Clinical Center (PENN+PLUS CC)U01DK106892 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI NEWMAN, DIANE K., SMITH, ARIANA L · 2015 to 2024
$5.4M
PLUS Loyola Clinical CenterU01DK106898 · NIDDK · LOYOLA UNIVERSITY CHICAGO · PI BRUBAKER, LINDA, FITZGERALD, COLLEEN MARIE · 2015 to 2024
$4.7M
Prevention of LUTS: Bladder Health Clinical Center, UC San Diego SiteU01DK106827 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LACOURSIERE, DAPHNE YVETTE, LUKACZ, EMILY S. · 2015 to 2024
$4.5M
Pathways to LUTS Prevention: A Model for Public Education, Behavioral Skills, and Early DetectionU01DK106858 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCGWIN, GERALD · 2015 to 2024
$4.5M
LUTS PREVENTION IN ADOLESCENT GIRLS AND WOMEN ACROSS THE LIFESPANU01DK106853 · NIDDK · WASHINGTON UNIVERSITY · PI SUTCLIFFE, SIOBHAN · 2015 to 2024
$4.0M
The Truly Healthy Bladder: Understanding Normal As A Pathway To Prevention Of Lower Urinary Tract Symptoms In WomenU01DK106893 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LOW, LISA KANE · 2015 to 2024
$3.8M
Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Yale Clinical Research CenterU01DK106908 · NIDDK · YALE UNIVERSITY · PI RICKEY, LESLIE M. · 2015 to 2024
$3.5M
NORTHWESTERN UNIVERSITY PLUS CLINICAL SITEU01DK126045 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GRIFFITH, JAMES WILLIAM, SIMON, MELISSA A. · 2020 to 2024
$1.4M
NIDDK NIH HHS U01 DK106827NIDDK NIH HHS U01 DK106853NIDDK NIH HHS U01 DK106858NIDDK NIH HHS U01 DK106892NIDDK NIH HHS U01 DK106893NIDDK NIH HHS U01 DK106898NIDDK NIH HHS U01 DK106908NIDDK NIH HHS U01 DK126045NIDDK NIH HHS U24 DK106786
6 · The paper itself

Abstract

Despite the established association with lower urinary tract symptoms, the relationship between a healthy bladder and the urogenital microbiome is unknown. This observational cohort study of 435 community-dwelling women examined bladder health and function using a validated instrument. Voided urine samples were self-collected, shipped to a repository, and underwent 16S rRNA amplicon sequencing. Two hundred seventy-four (56%) samples were retained following a limit-of-detection analysis for low biomass samples. A differential abundance analysis showed that IMPORTANCE: There is increasing awareness that human microbiomes impact health and modulate certain health conditions. Recently, investigators developed a validated assessment of bladder health in adult women. This advance facilitated evaluation of the urogenital microbiome, across the adult lifespan and across the spectrum of bladder health in a population-based, observational study.

Indexed as

MicrobiotaUrinary BladderUrogenital SystemAdultAgedCohort StudiesFemaleHumansIndependent LivingMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbladder healthfemalemicrobiomeurinaryurobiome

Identifiers

PMID41099505
PMCPMC12625691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.