Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Belinda E HetzlerDepartment of Chemistry, New York University, New York, New York 10003, United States.ORCID 0000-0002-0372-9126
Prashant DonthamsettiDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Robert M WolesenskyDepartment of Chemistry, New York University, New York, New York 10003, United States.ORCID 0000-0002-0119-8413
Cherise StanleyDepartment of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.
Ehud Y IsacoffDepartment of Molecular and Cell Biology, University of California, Berkeley, California 94720, United States.ORCID 0000-0003-4775-9359
Dirk TraunerDepartment of Chemistry, New York University, New York, New York 10003, United States.ORCID 0000-0002-6782-6056
Funding
NDC for the Optical Control of Biological FunctionPN2EY018241 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2006 to 2015
$37.5M
Transport Cycle and Inhibition of Human Na+-dicarboxylate Cotransporter NaDC3R01NS108151 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DANENG WANG · 2018 to 2026
$4.1M
Optical control of neuromodulatory GPCRsRF1MH123246 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD, TRAUNER, DIRK HARTWIG · 2020 to 2020
$3.3M
Optical Control of the Actin CytoskeletonR01GM126228 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DIRK HARTWIG TRAUNER · 2018 to 2026
$2.6M
Optical Control of Synaptic Transmission for in Vivo Analysis of Brain Circuits and BehaviorU01NS090527 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD, KRAMER, RICHARD H · 2014 to 2016
$2.4M
Optogenetic Vision RestorationR01EY028240 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLANNERY, JOHN GERARD, ISACOFF, EHUD · 2018 to 2021
$1.6M
Voltage Gating MechanismsR01GM117051 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2016 to 2019
$1.3M
Acquisition of a Cryoprobe for a 600 MHz NMR SpectrometerS10OD016343 · OD · NEW YORK UNIVERSITY · PI KROGSGAARD, MICHELLE, TRAASETH, NATHANIEL J. · 2014 to 2014
$360k
Development of an Optogenetic Toolkit to Dissect Dopamine Receptor Function in vivoF32DA044696 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DONTHAMSETTI, PRASHANT CHANDRA · 2017 to 2019
Dopamine D1 receptor (D1R) plays key roles in health and disease. D1R is broadly expressed throughout the brain and body and is dynamically activated in response to endogenous dopamine, making it difficult to target this receptor with sufficient precision. We previously developed a robust light-activatable, tetherable agonist for D1R, wherein a temporally precise photoswitch (the P compound) binds to a genetically encoded membrane anchoring protein (the M protein) in specific brain locations and cell types. Here we extended our approach by developing a complementary antagonist P compound that could be used to block specific populations of D1R in the brain with precise timing. Together, we have generated a robust toolkit for interrogating D1R function in the brain with unprecedented precision.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Reversible Antagonism of Dopamine D1 Receptor Using a Photoswitchable Remotely Tethered Ligand. · full record | OpenQuestion