Evidence map›Paper›PMID 41099136›Full record

ArticleEmerging microbes & infections2025

Developing accessible and affordable tests to support mpox immunosurveillance and vaccine studies.

Sian E Faustini, Scott Jones, Christopher A Green, Ashley D Otter, Alex G Richter, Jennifer L J Heaney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sian E FaustiniClinical Immunology Services, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, UK.
Scott JonesEmerging Pathogen Serology Group, Vaccine Development Evaluation and Preparedness Centre, UK Health Security Agency, Porton Down, Wiltshire, UK.
Christopher A GreenSchool of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Birmingham, UK.
Ashley D OtterEmerging Pathogen Serology Group, Vaccine Development Evaluation and Preparedness Centre, UK Health Security Agency, Porton Down, Wiltshire, UK.
Alex G RichterClinical Immunology Services, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, UK.
Jennifer L J HeaneyClinical Immunology Services, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mpox is an ongoing threat to international health security requiring ongoing research. Antibody tests are needed for surveillance studies to understand clinical and sub-clinical transmission risks and respond to outbreaks. With the objective of having a simple and low-cost antibody platform, we developed a laboratory ELISA kit combining four immunodominant mpox proteins to quantify mpox IgG antibody concentration and determine serostatus. The combined assay returns one data point (mpox IgG ratio) per sample. UK serum samples from individuals' post-infection, post-vaccination and those with no known history of mpox infection or vaccination were used to evaluate the assay. The assay effectively discriminated individuals with prior infection or vaccination combined from those without (AUC ·98 [95% CI ·95-1·00],

Indexed as

Mpox, MonkeypoxPublic Health SurveillanceAdultEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GMaleSensitivity and SpecificityUnited KingdomVaccinationImmunoglobulin GantibodyinfectionMpoxseroepidemiologyvaccination

Identifiers

PMID41099136
PMCPMC12581779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.