Evidence map›Paper›PMID 41099041›Full record

ArticleBMJ public health2025

Epidemiology of early-onset and late-onset invasive infections in Australian neonates and infants: a retrospective multicentre study.

Phoebe C M Williams, Mona Mostaghim, Jackson Harrison, Monica Lahra, Mark Greenhalgh, Matthew O'Sullivan, Michael Maley, Ju-Lee Oei, Archana Koirala, Himanshu Popat and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Phoebe C M WilliamsSydney Institute for Infectious Diseases, School of Public Health, Faculty of Medicine, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-2250-0594
Mona MostaghimSydney Institute for Infectious Diseases, School of Public Health, Faculty of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
Jackson HarrisonSydney Institute for Infectious Diseases, School of Public Health, Faculty of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
Monica LahraDepartment of Microbiology, NSW Health Pathology, Sydney, New South Wales, Australia.
Mark GreenhalghDepartment of Neonatology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Matthew O'SullivanCentre for Infectious Diseases and Microbiology, NSW Health Pathology, Sydney, New South Wales, Australia.
Michael MaleyDepartment of Microbiology & Infectious Diseases, NSW Health Pathology, Liverpool, New South Wales, Australia.
Ju-Lee OeiDepartment of Neonatology, The Royal Hospital for Women, Randwick, New South Wales, Australia.
Archana KoiralaSydney Institute for Infectious Diseases, School of Public Health, Faculty of Medicine, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-2567-8825
Himanshu PopatDepartment of Neonatology, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.ORCID https://orcid.org/0000-0002-6991-9686
Kei LuiNewborn Care, Australian and New Zealand Neonatal Network, Royal Hospital for Women, National Perinatal Epidemiology and Statistic Unit, University of NSW, Sydney, New South Wales, Australia.
Brendan McMullanSchool of Women & Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
Pamela PalasanthiranSchool of Women & Children's Health, University of New South Wales, Sydney, New South Wales, Australia.
Alison KessonDepartment of Infectious Diseases and MIcrobiology, Sydney Children's Hospital, Westmead, New South Wales, Australia.
David IsaacsDepartment of Infectious Diseases and MIcrobiology, Sydney Children's Hospital, Westmead, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9593-7378
Adam William BartlettSchool of Women & Children's Health, University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-7532-9316

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There has been little decline in neonatal mortality rates over recent decades, and this is now further challenged by the rising prevalence of antimicrobial resistance. In Australia, the incidence of neonatal sepsis is low on a global scale, yet there are increasingly frequent outbreaks of multidrug-resistant (MDR) infections in neonatal intensive care units, alongside rising rates of colonisation with MDR bacteria. Methods: We analysed positive blood and cerebrospinal fluid cultures collected from infants (aged 0 to ≤180 days) across five clinical sites in Australia between 2010 and 2019, to determine evolving antimicrobial susceptibility profiles. Results: After excluding presumed contaminants, we analysed 743 pathogenic bacterial isolates cultured from 624 neonates and infants with early-onset (≤72 hours), late-onset (>72 hours to ≤28 days) and very late-onset (>28 days to ≤180 days) infections. Conclusions: Although empiric antimicrobial regimens remain adequate for most pathogens causing infections in neonates and infants in Australia, there is an increasing burden of invasive infections caused by gram-negative bacteria. Ongoing surveillance is necessary to ensure empiric antimicrobial guidelines remain efficacious and appropriate.

Indexed as

Age FactorsDisease Transmission, InfectiousEpidemicsEpidemiology

Identifiers

PMID41099041
PMCPMC12519648

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.