Evidence map›Paper›PMID 41098986›Full record

ArticleFrontiers in medicine2025

Triglyceride-glucose index as a prognostic marker of endovascular thrombectomy in patients with ischemic stroke: a retrospective study.

Zhaoliang Sun, Xuchen Meng, Zixian Mei, Tanjun Deng, Xin Lv, Jiexi Xiao, Lin Zhu, Dingzhong Tang, Weijie Zhong, Yi Li

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zhaoliang Sun *Department of Neurosurgery, Ninth People's Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuchen Meng *Department of Neurosurgery, Ninth People's Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zixian Mei *Department of Neurosurgery, Ninth People's Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tanjun DengDepartment of Neurosurgery, Ninth People's Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xin LvDepartment of Neurosurgery, Ninth People's Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiexi XiaoDepartment of Neurosurgery, Ninth People's Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lin ZhuDepartment of Neurosurgery, Ninth People's Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dingzhong TangDepartment of Neurology Medical, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, China.
Weijie ZhongDepartment of Neurosurgery, Ninth People's Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi LiDepartment of Neurosurgery, Ninth People's Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study investigates the association between the triglyceride-glucose (TyG) index, a surrogate marker for insulin resistance, and clinical outcomes in patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT). Methods: This retrospective study included 179 patients with AIS who underwent EVT. The TyG index was calculated as ln[triglycerides (TGs) (mg/dL) × glucose (mg/dL)/2] from admission blood samples. The primary outcome was functional status at 90 days post-stroke, assessed by the modified Rankin Scale (mRS). A multivariate logistic regression analysis was performed to evaluate the association between the TyG index and outcomes after adjusting for potential confounders. Results: Among the 179 patients, 77 (43.0%) had favorable outcomes (mRS ≤ 2) and 102 (57.0%) had poor outcomes (mRS > 2) at 90 days post-stroke. The TyG index was significantly higher in the poor outcome group compared to the favorable outcome group. The receiver operating characteristic curve analysis showed that the TyG index (area under the ROC curve, AUC = 0.714) had superior predictive value compared with either glucose (AUC = 0.618) or TGs (AUC = 0.574) alone or their combination (AUC = 0.633). The optimal cut-off value for the TyG index was 8.795, with a sensitivity of 0.569 and a specificity of 0.753. A multivariate logistic regression analysis confirmed that the TyG index was independently associated with poor outcomes after adjusting for conventional prognostic factors. Adding the TyG index to a prediction model significantly improved its performance (AUC from 0.776 to 0.826, Conclusion: Elevated TyG index is independently associated with poor outcomes in patients with AIS after EVT. The TyG index demonstrates superior predictive performance compared to individual metabolic parameters and significantly improves outcome prediction when added to conventional prognostic factors. These findings suggest that the TyG index may serve as a valuable prognostic marker for risk stratification in patients with AIS undergoing EVT.

Indexed as

acute ischemic strokeendovascular thrombectomyprognosisprognostic markertriglyceride-glucose index

Identifiers

PMID41098986
PMCPMC12518228

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