Control of Subpopulation Fractions in a Population of Bistable Cells.

Dylan Hirsch, Sylvia Herbert

Abstract read

In one paragraph

Article in IEEE control systems letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dylan HirschDepartment of Mechanical and Aerospace Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093.

Sylvia HerbertDepartment of Mechanical and Aerospace Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093.

Funding

Training in Multi-Scale Analysis of Biological Structure and FunctionT32EB009380 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrew D. McCulloch, Padmini Rangamani · 2009 to 2026

$4.8M

Genetically Programmed Pancreatic Organoids with Self-Adaptive Multi-Lineage Population ControlR01HD105947 · NICHD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEISS, RON · 2021 to 2025

$3.2M

NIBIB NIH HHS T32 EB009380NICHD NIH HHS R01 HD105947

6 · The paper itself

Abstract

Bistable genetic circuits have long been studied in systems and synthetic biology, with notable recent work focused on controlling the phenotypic composition of populations with such circuits. Here, we build on previous literature to theoretically characterize a mechanism by which cells with bistable circuits can use quorum sensing to drive the population to arbitrary phenotypic compositions. We in particular investigate the ability of a proportional controller to accomplish this task on ideal and non-ideal plants, providing performance guarantees and, under additional assumptions, guarantees of almost-global convergence to a desirable population equilibrium.

Indexed as

biomolecular systemscellular dynamicsnonlinear output feedbacksystems biology

Identifiers

PMID41098971

DOI10.1109/LCSYS.2025.3613753

PMCPMC12520325

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.