Evidence map›Paper›PMID 41098970›Full record

ArticleInternational journal of endocrinology2025

Causal Relationship Between Genetically Determined Free Fatty Acids and Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study.

Kenan Li, Yuyin Liang, Xiumin Zhang, Piao Hu, Manyi Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kenan LiDepartment of Infectious Diseases, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.
Yuyin LiangDepartment of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong, China.
Xiumin ZhangDepartment of Refractive Clinic, Hangzhou Aier Eye Hospital, Hangzhou, Zhejiang, China.
Piao HuDepartment of Infectious Diseases, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0001-6464-7258
Manyi HuDepartment of Colorectal Surgery, Jinhua Municipal Central Hospital, Jinhua, Zhejiang, China.ORCID https://orcid.org/0009-0001-1957-208X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate whether the ten-individual plasma-level of free fatty acids (FFAs) affect the risk of nonalcoholic fatty liver disease (NAFLD) which is featured by triglycerides (TGs) deposition because the observational studies are limited and conflicting about the causal effect between FFAs and NAFLD. Design and Methods: This analysis was a large genome-wide association study (GWAS) summary statistic. Fourteen independent single-nucleotide polymorphisms (SNPs) without linkage disequilibrium ( Results: The result demonstrated that 10 individual FFAs were not significantly associated with NAFLD. Conclusion: The evidence to support the causal association of the individual plasma FFAs with NAFLD is insufficient in this study.

Indexed as

causalityFFAsMendelian randomization analysisNAFLD

Identifiers

PMID41098970
PMCPMC12520819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.