Evidence map›Paper›PMID 41098964›Full record

ArticleBlood vessels, thrombosis & hemostasis2025

Nasal RADA16 hydrogel application decreases epistaxis severity scores in adults with hereditary hemorrhagic telangiectasia.

Avraham Adelman, Eunice Im, Lindsey Jackson, Anil Patel, Nikita Chapurin, Christina Eagan, Ali Ataya, Marc Zumberg, Jennifer K Mulligan, Carl Atkinson and 2 more

Abstract read
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In one paragraph

Article in Blood vessels, thrombosis & hemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Avraham AdelmanDivision of Rhinology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL.
Eunice ImDivision of Rhinology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL.
Lindsey JacksonDivision of Rhinology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL.
Anil PatelDivision of Rhinology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL.
Nikita ChapurinDivision of Rhinology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL.
Christina EaganDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL.
Ali AtayaDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL.
Marc ZumbergDivision of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL.
Jennifer K MulliganDivision of Rhinology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL.
Carl AtkinsonDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Brian C LoboDivision of Rhinology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL.
Jeb M JusticeDivision of Rhinology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

More than 90% of adults with hereditary hemorrhagic telangiectasia (HHT) experience epistaxis, which can be recurrent and cause significant morbidity. RADA16 is a self-assembling peptide hydrogel approved by the US Food and Drug Administration for hemostasis and wound healing. In this cohort study, we assessed the effectiveness of nasal RADA16 application in controlling HHT-related epistaxis. A retrospective chart review was performed on a cohort of adult patients who received nasal RADA16 without any other changes in treatment. Pre- and post-Epistaxis Severity Scores (ESS), hemoglobin, and hematocrit were collected to assess treatment response. Of the included patients (n = 22), there were 26 applications of RADA16. The cohort was 54.5% male and 86.4% White, had a mean age of 55.5 years, and had a predominantly

Identifiers

PMID41098964
PMCPMC12519286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.