ArticleACS ES&T engineering2025
Antibiotic Resistome Changes Associated with Different Types of Corrosion Inhibitors When Chlorine is Used as a Disinfectant.
Article in ACS ES&T engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drinking water distribution systems contain chlorine and metals that can promote antibiotic resistance. Corrosion inhibitors are required to prevent the leaching of metals into drinking water. While utilities have a choice of which corrosion inhibitor they employ, the impact of corrosion inhibitor type when combined with chlorine on antibiotic resistance is unknown. The objective of this research was to understand the impacts of zinc orthophosphate, sodium orthophosphate, and sodium silicate, three commonly used corrosion inhibitors, on antibiotic resistance when mixed with chlorine. Culture-based plating was paired with metagenomics analysis on lab-scale microcosms. The addition of all three corrosion inhibitors resulted in a significantly higher absolute abundance of antibiotic resistant bacteria with resistance to rifampicin, sulfamethoxazole, and vancomycin, while the addition of phosphate-based inhibitors (sodium orthophosphate and zinc orthophosphate) at 1 mg/L also resulted in significantly higher absolute abundance of ampicillin-resistant bacteria. Exposure to all three types of corrosion inhibitors and free chlorine led to significantly higher abundances of ARGs conferring resistance to the target antibiotics used in the phenotypic assessment. Observed changes in the resistomes compared to the controls were influenced by an enrichment in ARGs responsible for multidrug resistance and resistance to peptide antibiotics. In general, most of the ARGs were associated with chromosomes, but a significant increase in the number of ARGs colocated with plasmid and integron sequences was observed. In contrast, the abundance of viral-associated ARGs decreased in the treatments compared to the controls. These results highlight the importance of corrosion inhibitor selection and the potential impacts on antibiotic resistance in potable water systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.