Evidence map›Paper›PMID 41098883›Full record

ArticlePNAS nexus2025

New methods on the block: Taxonomic identification of archaeological bones in resin-embedded sediments through paleoproteomics.

Zandra Fagernäs, Gaudry Troché, Paul Goldberg, Jean-Jacques Hublin, Shannon P McPherron, William Chase Murphree, Jesper V Olsen, Dennis Sandgathe, Nikolay Sirakov, Marie Soressi and 5 more

Abstract read
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zandra FagernäsGlobe Institute, University of Copenhagen, Øster Voldgade 5-7, Copenhagen 1350, Denmark.ORCID https://orcid.org/0000-0003-2667-3556
Gaudry TrochéGlobe Institute, University of Copenhagen, Øster Voldgade 5-7, Copenhagen 1350, Denmark.
Paul GoldbergInstitute for Archaeological Science, University of Tübingen, Rümelinstr. 23, Tübingen 72070, Germany.ORCID https://orcid.org/0000-0002-7059-1446
Jean-Jacques HublinChaire de Paléoanthropologie, Collège de France, 11 Pl. Marcelin Berthelot, Paris 75231, France.ORCID https://orcid.org/0000-0001-6283-8114
Shannon P McPherronDepartment of Human Origins, Max Planck Institute for Evolutionary Anthropology, Deutscher Pl. 6, Leipzig 04103, Germany.
William Chase MurphreeICArEHB-Interdisciplinary Center for Archaeology and the Evolution of Human Behaviour, Universidade do Algarve, Campus de Gambelas, FCHS K2, Faro 8005-139, Portugal.ORCID https://orcid.org/0000-0003-0781-2039
Jesper V OlsenNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Blegdamsvej 3B, Copenhagen 2200, Denmark.ORCID https://orcid.org/0000-0002-4747-4938
Dennis SandgatheDepartment of Archaeology, Simon Fraser University, 8888 University Drive, Burnaby, Bc V5A-1S6, Canada.ORCID https://orcid.org/0000-0002-0998-7345
Nikolay SirakovNational Institute of Archaeology with Museum, Bulgarian Academy of Sciences, 2 Saborna Str., Sofia 1000, Bulgaria.
Marie SoressiFaculty of Archaeology, University of Leiden, Einsteinweg 2, Leiden 2333, Netherlands.ORCID https://orcid.org/0000-0003-1733-7745
Tsenka TsanovaDepartment of Human Origins, Max Planck Institute for Evolutionary Anthropology, Deutscher Pl. 6, Leipzig 04103, Germany.ORCID https://orcid.org/0000-0002-1060-0849
Alain TurqPacea UMR 5199, University of Bordeaux, Bât B2 Allée Geoffroy Saint-Hilaire CS 50023, Mouzens 33615, France.
Michael WiererProteomics Research Infrastructure, University of Copenhagen, Blegdamsvej 3B, Copenhagen 2200, Denmark.ORCID https://orcid.org/0000-0002-0356-5571
Frido WelkerGlobe Institute, University of Copenhagen, Øster Voldgade 5-7, Copenhagen 1350, Denmark.ORCID https://orcid.org/0000-0002-4846-6104
Vera AldeiasICArEHB-Interdisciplinary Center for Archaeology and the Evolution of Human Behaviour, Universidade do Algarve, Campus de Gambelas, FCHS K2, Faro 8005-139, Portugal.ORCID https://orcid.org/0000-0002-7680-182X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of biomolecular studies of past organisms with geoarchaeological studies can significantly improve our understanding of the relative chronology and context of archaeologically (in)visible behaviors. However, the complexity and sedimentological heterogeneity of archaeological deposits at a microscopic scale is often not taken into consideration in biomolecular studies. Here, we investigate the preservation and retrieval of paleoproteomic data from bone fragments embedded in Pleistocene resin-impregnated sediment blocks. We show that resin impregnation has minimal effect on skeletal protein taxonomic identifications in modern skeletal material but observe an increase in oxidation of methionines. We then successfully retrieve proteins from resin-impregnated blocks from the Paleolithic sites of Bacho Kiro Cave, La Ferrassie, and Quinçay. The taxonomic identifications of minute bones encased in resin are in line with previous analyses of the faunal communities of these sites, with a diversity of taxa (

Indexed as

archaeologyhuman evolutionmicromorphologypaleoproteomicszooarchaeology

Identifiers

PMID41098883
PMCPMC12518019

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.