ReviewJGH open : an open access journal of gastroenterology and hepatology2025
Gastroesophageal Reflux Disease (GERD) and Risk of Incident Acute Myocardial Infarction: A Systematic Review and Meta-Analysis of Cohort Studies.
Review in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gastroesophageal Reflux Disease (GERD) and Risk of Incident Acute Myocardial Infarction: A Systematic Review and Meta-Analysis of Cohort Studies.JGH open : an open access journal of gastroenterology and hepatology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: Recent evidence suggests that gastroesophageal reflux disease (GERD) is associated with cardiovascular diseases, including increased coronary artery calcification. However, whether GERD is a risk factor for acute myocardial infarction (AMI) remains uncertain. This study aims to clarify this association through a systematic review and meta-analysis. Methods and Results: We searched MEDLINE and EMBASE databases from inception to January 2025, including cohort studies that compared AMI incidence in individuals with and without GERD. Relative risk (RR), hazard ratio (HR), and 95% confidence intervals (CIs) were extracted and combined using a random-effects model with the generic inverse variance method. Our meta-analysis included six cohort studies with 1 324 362 participants. Patients with GERD had a 27% increased risk of incident AMI compared to those without GERD (pooled RR: 1.27, 95% CI: 1.13-1.47; Conclusion: These findings suggest that GERD may contribute to AMI risk, highlighting the need for further research into preventive strategies and targeted interventions, such as acid suppression therapy and lifestyle modifications, to mitigate cardiovascular risk in GERD patients. Future studies should also explore mechanistic pathways to better understand this link and improve patient care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.