ArticleFrontiers in immunology2025
NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) reflect disease activity and renal remission in patients with lupus nephritis.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07780045 (Emerging Inflammatory Biomarkers), which is not on this map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Emerging Inflammatory Biomarkers (SII and SIRI) for Predicting Disease Activity, Renal Flares and Outcomes in Lupus Nephritis: A Prospective Observational Study
Who cites it
17 citing papers in PubMed.
- Systemic inflammatory indices for predicting severe placenta accreta spectrum: a retrospective cohort study.Journal of global health · 2026Article
- Discriminating Osteoarticular Infection Bacterial Aetiology Using Immune-Inflammatory Biomarkers.Microorganisms · 2026Article
- Peripheral Blood Neutrophil-to-Lymphocyte Ratio Combined With Fibrinogen-to-Albumin Ratio Assists in Identifying Systemic Lupus Erythematosus Activity and Lupus Nephritis.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Preoperative Inflammatory Markers as Predictors of Ovarian Tumor Malignancy: A Retrospective Diagnostic Study.Medicina (Kaunas, Lithuania) · 2026Observational
- An Evaluation of Novel Inflammatory Biomarkers in Children withPathogens (Basel, Switzerland) · 2026Article
- Inflammatory blood count ratios discriminate disease activity and remain persistently elevated during glucocorticoid-free remission in ANCA-associated vasculitis.Clinical and experimental medicine · 2026Article
- Article
- Correlation Between Systemic Inflammation Response Index and Systemic Immune-Inflammation Index and Disease Activity of Lupus Nephritis in Children.Children (Basel, Switzerland) · 2026Article
- Systemic Immune-Inflammation Index and Clinical Predictors of Atypical PRES in Eclampsia: Higher Blood Pressure and Inflammatory Burden Drive Multi-Regional Involvement.Biomedicines · 2026Article
- Limited Predictive Value of NLR, PLR and SII in Thrombosed Hemorrhoids: A Real-World Analysis.Life (Basel, Switzerland) · 2026Article
- Systemic inflammatory indices SIRI, AISI, and PWR are associated with sarcopenic obesity in middle-aged and older chinese adults: a cross-sectional study.Nutrition & metabolism · 2026Article
- A risk prediction model based on immune-inflammatory-nutritional indicators for predicting 28-day mortality in sepsis patients with acute respiratory distress syndrome.Frontiers in nutrition · 2026Article
- Blood-based inflammatory biomarkers in ovarian cancer: addressing the challenge of early detection, metastasis, and prognostic stratification.Oncology reviews · 2026Review
- Pathogenesis of renal involvement in primary Sjögren's disease: convergence of multifactorial mechanisms on immune dysregulation.Frontiers in immunology · 2026Review
- Platelets in systemic lupus erythematosus: from hemostatic allies to pathogenic drivers.Frontiers in immunology · 2026Review
- Application Value of Blood Routine-Derived Indices for the Evaluation of Disease Activity in Systemic Lupus Erythematosus.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2026Article
- A Prognostic Model Based on Immune-Inflammatory-Nutritional Indicators for 28-Day Mortality in Sepsis Patients with Acute-on-Chronic Liver Failure.Journal of inflammation research · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Objective: To evaluate the value of NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) in reflecting disease activity and induction therapy remission in patients with lupus nephritis (LN). Methods: Active LN patients from STAR cohort were enrolled. We analyzed the trends of complete blood count parameters with Generalized Estimated Equation. Bivariate correlation analyses, Chi-square tests, Results: 310 active LN patients were enrolled in the study. All patients had active lupus with SLEDAI-2K 17.1 ± 6.1, median 24h-Urine Protein (UTP) level of 3.1 (1.5, 5.4) g. During the 12-month follow-up of induction therapy, NLR and PLR showed a decreasing trend. Both baseline NLR and SII were positively correlated with baseline UTP and serum creatinine (SCr) levels ( Conclusion: Our findings suggested that NLR and SII were valuable indicators of disease activity in LN, correlating with UTP, SCr and AI score of renal pathology. NLR, PLR and SII provided us a quick, simple and cost-effective supervision way in monitoring and managing LN patients.
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