ArticleJournal of inflammation research2025
The Pomegranate Peel Polyphenols Protects Acne Vulgaris by Regulating Inflammation Through Notch/NF-κB Signal Pathway.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Chemical Characteristics and Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pomegranate peel is a kind of traditional Chinese medicine for treating acne. Its main active ingredient is pomegranate peel polyphenols(PPPs), but its mechanism is not clear. Inflammatory response is still the focus of current treatment. Interestingly, Notch signaling is considered to be a key regulator of macrophage activation, which can promote the occurrence and development of Acne vulgaris (AV) by activating nuclear factor kappa-B (NF-κB) to produce a large number of inflammatory factors. Objective: This study aims to explore the potential mechanism of PPPs for treating AV. Methods: An in-vivo model of acne was established by injecting SD rats with Cutibacterium acnes( Results: PPPs improved the levels of IL-1α, TNF-α, IL-6, IL-8 and IL-12 in serum and pathological skin lesions of SD rats induced by Conclusion: PPPs can inhibit Notch/NF-κB signaling pathway, reduce inflammatory response, and exert anti-acne effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.