ArticleJournal of inflammation research2025
Risk Factor Analysis for Recurrence of Subacute Necrotizing Lymphadenitis in Children.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To analyze the clinical features of subacute necrotizing lymphadenitis (SNL) in children and to explore the risk factors for recurrence. Methods: A retrospective case-control method was used to analyze 91 children with SNL admitted to Wuhan Children's Hospital from June 2016 to December 2024. A total of 91 children diagnosed with SNL were included, including 8 cases with recurrence and 83 without recurrence. Sixty-seven of the 91 children with SNL included underwent lymph node pathology, and 24 did not undergo lymph node biopsy. The 91 clinically diagnosed SNL patients were divided into a recurrence group and a non-recurrence group. The 67 SNL cases that underwent lymph node pathological examination were also divided into recurrence and non-recurrence groups. Baseline information, clinical manifestations, and laboratory data were compared between the two groups, and univariate analysis was performed on the difference indicators. Binary logistic regression analysis was then used to explore the risk factors for recurrent SNL. Results: Analyze of 91 SNL patients revealed significant differences in age at onset ( Conclusion: Older age of onset and elevated complement C3 may be risk factors for recurrence of SNL, with particular attention to elevated complement C3, and clinical follow-up is needed for this group of children.
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