ReviewFrontiers in behavioral neuroscience2025
Neurosteroids: a lifelong impact on brain health.
Review in Frontiers in behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Harnessing the neuroprotective potential of estrogen in Parkinson's disease: an insight into molecular mechanisms and therapeutic approaches.Metabolic brain disease · 2026Review
- Hypothesis on PTSD Pathophysiology: Role of CRH, Noradrenaline, and Glucocorticoid Receptors in an Amygdala-Centered Closed-Loop System.International journal of molecular sciences · 2026Article
- Impact of Orchiectomy on Oxidative Stress-Induced Neurodegeneration in the Male Rat Retina: A Proteomic Analysis.Antioxidants (Basel, Switzerland) · 2026Article
- GABAFrontiers in pharmacology · 2026Review
- Epilepsy and exercise: a narrative review on the crucial role of neurosteroids in modulating GABAergic neurotransmission.Brain communications · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurosteroids are critical regulators of brain function, exerting profound effects on neurodevelopment, emotional regulation, cognition, and resilience to stress across the lifespan. Synthesized endogenously in the brain and peripheral tissues, neurosteroids modulate neural circuits through both genomic and non-genomic mechanisms. This review synthesizes current evidence on the roles of neurosteroids from fetal development through advanced biological aging, emphasizing their involvement in neuronal plasticity, synaptic modulation, myelination, and neurogenesis. We explore how neurosteroid dysregulation contributes to mood and cognitive disorders and highlight age- and sex-related changes in neurosteroid synthesis which may impact risk. Lifestyle factors including diet, exercise, and mindfulness are also examined for their ability to modulate neurosteroidogenesis and promote brain health. By integrating findings across developmental stages and physiological states, we underscore the functional roles of neurosteroids as modulators of emotional and cognitive states across the lifespan, and advocate for deeper investigation into neurosteroid-based intervention for across indications and throughout the lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.