Evidence map›Paper›PMID 41098628›Full record

ArticleACS ES&T air2025

Differential

Alexandra Noël, Chase K Glenn, Omar El Hajj, Anita Anosike, Kruthika Kumar, Muhammad Isa Abdurrahman, Steven Flanagan, Mac A Callaham, E Louise Loudermilk, Elijah T Roberts and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS ES&T air, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mitigating the Impact of Air Pollution on Human Health.Environmental science & technology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alexandra NoëlSchool of Veterinary Medicine, Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
Chase K GlennSchool of Environmental, Civil, Agricultural, and Mechanical Engineering, University of Georgia, Athens, Georgia 30602, United States.
Omar El HajjSchool of Environmental, Civil, Agricultural, and Mechanical Engineering, University of Georgia, Athens, Georgia 30602, United States.
Anita AnosikeSchool of Environmental, Civil, Agricultural, and Mechanical Engineering, University of Georgia, Athens, Georgia 30602, United States.
Kruthika KumarSchool of Environmental, Civil, Agricultural, and Mechanical Engineering, University of Georgia, Athens, Georgia 30602, United States.
Muhammad Isa AbdurrahmanSchool of Environmental, Civil, Agricultural, and Mechanical Engineering, University of Georgia, Athens, Georgia 30602, United States.
Steven FlanaganUSDA Forest Service Southern Research Station, Athens, Georgia 30602, United States.
Mac A CallahamUSDA Forest Service Southern Research Station, Athens, Georgia 30602, United States.
E Louise LoudermilkUSDA Forest Service Southern Research Station, Athens, Georgia 30602, United States.
Elijah T RobertsDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Jonathan H ChoiDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.
Bin BaiSchool of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Pengfei LiuSchool of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID https://orcid.org/0000-0001-7280-9720
I Jonathan AmsterDepartment of Chemistry, University of Georgia, Athens, Georgia 30602, United States.ORCID https://orcid.org/0000-0001-7523-5144
Joseph O'BrienUSDA Forest Service Southern Research Station, Athens, Georgia 30602, United States.
Rawad SalehSchool of Environmental, Civil, Agricultural, and Mechanical Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID https://orcid.org/0000-0002-4951-7962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the effects of the fuel moisture content and photochemical aging on the toxicity of smoke particulate matter (PM) emissions in simulated wildland fires. We burned fuel beds consisting of surface fuels and duff under moderate and low moisture contents, representative of prescribed fires (Rx) and drought-induced wildfires (Wild), respectively. The Wild emissions were photochemically aged in an oxidation flow reactor (Wild-Aged). We exposed human bronchial epithelial cells to PM extracts from each permutation. PM extracts from all experimental permutations (Rx, Wild, Wild-Aged) induced oxidative stress, evidenced by a significant increase in 8-isoprostane concentration in the cell media compared to control. However, the increase of 8-isoprostane was significantly less in Wild-Aged compared to that in Wild and Rx, indicating loss of oxidative potential due to photochemical aging. Based on the release of lactate dehydrogenase in the cell media, the level of lipid peroxidation, and the magnitude of gene fold-changes, Rx PM extracts were more toxic than Wild. Chemical composition analysis suggests that toxicity was driven by levels of aromatic species in the PM, which were highest in Rx, followed by Wild and Wild-Aged. Overall, these results highlight the complex dependence of the toxicity of wildland-fire smoke on combustion conditions and atmospheric processing.

Indexed as

atmospheric processingbiotransformationoxidative stressparticulate matterprescribed fireswildfires

Identifiers

PMID41098628
PMCPMC12519478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.