Evidence map›Paper›PMID 41098565›Full record

ArticleACS pharmacology & translational science2025

Genetic Deletion of the Purinergic Receptor

Cecilia Astigiano, Elisa Principi, Sara Pintus, Andrea Benzi, Serena Baratto, Chiara Panicucci, Mario Passalacqua, Juan Sierra-Marquez, Annette Nicke, Francesca Antonini and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Cecilia AstigianoDepartment of Experimental Medicine, Section of Biochemistry, University of Genoa, 16132 Genoa, Italy.
Elisa PrincipiCenter of Translational and Experimental Myology, IRCCS Istituto G. Gaslini, 16147 Genoa, Italy.
Sara PintusCenter of Translational and Experimental Myology, IRCCS Istituto G. Gaslini, 16147 Genoa, Italy.
Andrea BenziDepartment of Experimental Medicine, Section of Biochemistry, University of Genoa, 16132 Genoa, Italy.
Serena BarattoCenter of Translational and Experimental Myology, IRCCS Istituto G. Gaslini, 16147 Genoa, Italy.
Chiara PanicucciCenter of Translational and Experimental Myology, IRCCS Istituto G. Gaslini, 16147 Genoa, Italy.
Mario PassalacquaDepartment of Experimental Medicine, Section of Biochemistry, University of Genoa, 16132 Genoa, Italy.
Juan Sierra-MarquezWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, 80336 Munich, Germany.
Annette NickeWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, 80336 Munich, Germany.ORCID https://orcid.org/0000-0001-6798-505X
Francesca AntoniniCore facilities Department of Research and Diagnostics, IRCCS Istituto G. Gaslini, 16147 Genoa, Italy.
Genny Del ZottoCore facilities Department of Research and Diagnostics, IRCCS Istituto G. Gaslini, 16147 Genoa, Italy.
Annunziata Gaetana CicatielloDepartment of Clinical Medicine and Surgery, University of Naples "Federico II", 80138 Naples, Italy.
Lizzia RaffaghelloMolecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Tanja Rezzonico JostInstitute of Oncology Research (IOR), 6500 Bellinzona, Switzerland.
Fabio GrassiIstituto Nazionale Genetica Molecolare ''Romeo ed Enrica Invernizzi'', 20122 Milan, Italy.
Santina BruzzoneDepartment of Experimental Medicine, Section of Biochemistry, University of Genoa, 16132 Genoa, Italy.ORCID https://orcid.org/0000-0003-2034-3716
Claudio BrunoCenter of Translational and Experimental Myology, IRCCS Istituto G. Gaslini, 16147 Genoa, Italy.
Elisabetta GazzerroUnit of Muscle Research, Experimental and Clinical Research Center, Charité Universitätsmedizin and Max Delbrück Research Center for Molecular Medicine, 10627 Berlin, Germany.ORCID https://orcid.org/0000-0003-2428-0302

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limb-girdle muscular dystrophy R3 (LGMDR3), a rare genetic disorder characterized by progressive impairment of limb, diaphragmatic, and respiratory muscles, is caused by loss-of-function mutations in the α-sarcoglycan gene (

Indexed as

fibrosisinflammationLGMDR3P2X7Rskeletal muscleα-sarcoglicanopathy

Identifiers

PMID41098565
PMCPMC12519300

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.