Evidence map›Paper›PMID 41098561›Full record

ArticleACS pharmacology & translational science2025

Catalytic Site Inhibitors of Group 1 Allergens Prevent Toll-like Receptor (TLR)4- and TLR1/2-Dependent Innate Responses in Keratinocytes and Airway Epithelial Cells Exposed to House Dust Mite Allergenic Extract.

Jihui Zhang, Jie Chen, Wen Hui Ng, Amir-Seena Saberi-Movahed, Zainab Rathore, Numa Sayed, Kristina George, Daniel Sequeira, David Garrod, Clive Robinson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jihui ZhangInstitute for Infection & Immunity, School of Health and Medical Sciences, City St George's University of London, Cranmer Terrace, London SW17 0RE, U.K.
Jie ChenInstitute for Infection & Immunity, School of Health and Medical Sciences, City St George's University of London, Cranmer Terrace, London SW17 0RE, U.K.
Wen Hui NgInstitute for Infection & Immunity, School of Health and Medical Sciences, City St George's University of London, Cranmer Terrace, London SW17 0RE, U.K.
Amir-Seena Saberi-MovahedInstitute for Infection & Immunity, School of Health and Medical Sciences, City St George's University of London, Cranmer Terrace, London SW17 0RE, U.K.ORCID https://orcid.org/0000-0001-9321-9113
Zainab RathoreInstitute for Infection & Immunity, School of Health and Medical Sciences, City St George's University of London, Cranmer Terrace, London SW17 0RE, U.K.ORCID https://orcid.org/0000-0002-4967-6015
Numa SayedInstitute for Infection & Immunity, School of Health and Medical Sciences, City St George's University of London, Cranmer Terrace, London SW17 0RE, U.K.
Kristina GeorgeInstitute for Infection & Immunity, School of Health and Medical Sciences, City St George's University of London, Cranmer Terrace, London SW17 0RE, U.K.
Daniel SequeiraInstitute for Infection & Immunity, School of Health and Medical Sciences, City St George's University of London, Cranmer Terrace, London SW17 0RE, U.K.ORCID https://orcid.org/0009-0001-7292-4048
David GarrodFaculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, U.K.
Clive RobinsonInstitute for Infection & Immunity, School of Health and Medical Sciences, City St George's University of London, Cranmer Terrace, London SW17 0RE, U.K.ORCID https://orcid.org/0000-0001-6253-7864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulated immune responses to domestic allergens are underlying events in atopic dermatitis (AD), an inflammatory disease of humans and domestic companion animals characterized by itching and eczema. The house dust mite (HDM) allergome, notably the cysteine protease group 1 allergens, is an important trigger of AD. This protease activity is implicated in innate mechanisms which both initiate and reinforce allergic sensitization, prompting interest in the design of protease inhibitors as a novel allergy therapy. We examined pyruvamide chemotype protease inhibitors on intracellular reactive oxidant species (ROS) production induced by HDM allergen extracts in HaCaT keratinocytes and identified promising topical and orally bioavailable candidates. We then explored the wider signaling network affected by this allergen inhibition in keratinocytes and airway epithelial cells (AECs). Optimized pyruvamides with different properties (

Indexed as

airway epitheliumallergenhouse dust mitekeratinocyteproteasetoll-like receptors

Identifiers

PMID41098561
PMCPMC12519262

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.