ArticleJournal of biomedical optics2025
Impact of sample handling protocols on soft tissue attenuation coefficient and morphology.
Article in Journal of biomedical optics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Significance: The use of tissue attenuation coefficients as biomarkers for disease detection is rising. However, especially for Aim: We aim to compare and evaluate common methods for sample handling and assess their impact on the optical attenuation and structural properties of Approach: Six different handling methods were tested: Direct freezing at Results: All sample handling methods showed a significant difference in tissue attenuation and morphology relative to the fresh tissue ( Conclusions: Understanding the impact of sample handling methods is critical to the accurate interpretation of morphology-based analysis. In the case of fresh tissue being unavailable, formalin-fixed and snap frozen tissue samples yield the best alternative with negligible effect sizes for colon tissue.
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