Evidence map›Paper›PMID 41098360›Full record

ArticleJournal of diabetes research2025

Advancing Understanding of Epilepsy and Type 1 Diabetes Mellitus: A Global Perspective on Research Trends and Future Directions.

Ruirui Zhang, Shenglin Wang, Sirui Chen, Junqiang Li, Dadong Luo, Kaiyun Jia, Yihe Lian, Tiancheng Wang, Xin Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruirui ZhangDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.ORCID https://orcid.org/0009-0006-3036-3285
Shenglin WangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing, China.ORCID https://orcid.org/0000-0003-4479-9937
Sirui ChenDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.ORCID https://orcid.org/0009-0003-0860-2495
Junqiang LiDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.ORCID https://orcid.org/0000-0003-4957-1130
Dadong LuoDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.ORCID https://orcid.org/0009-0005-2669-6303
Kaiyun JiaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing, China.ORCID https://orcid.org/0009-0004-9407-4891
Yihe LianDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing, China.ORCID https://orcid.org/0009-0008-2297-1728
Tiancheng WangDepartment of Neurology, Epilepsy Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.ORCID https://orcid.org/0000-0001-9701-8845
Xin TianDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Chongqing, China.ORCID https://orcid.org/0000-0003-1552-8919

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Evidence suggests a bidirectional relationship between epilepsy and Type 1 diabetes mellitus (T1DM), but the underlying mechanisms and overall research landscape remain incompletely understood. This study is aimed at delineating research trends and sharing pathogenic pathways between epilepsy and T1DM through a comprehensive bibliometric analysis and genetic investigation. Methods: We performed a systematic search of the Web of Science Core Collection database (from 1983 to 2024) to identify relevant publications on epilepsy and T1DM. Bibliometric tools (Bibliometrix and CiteSpace) were employed to analyze publication trends, major contributors, and research hotspots. Shared genes were identified via disease-gene association databases (GeneCards and OMIM), and differentially expressed genes (DEGs) were analyzed using GEO2R on GEO datasets. Results: A total of 217 publications were included. Publication output demonstrated exponential growth over the study period ( Conclusions: This study maps the evolving research landscape of epilepsy and T1DM, confirming autoimmunity as a key link. The identification of TSPO as a shared, upregulated gene provides novel molecular evidence for the connection between the two diseases and suggests TSPO as a potential target for future research and therapeutic strategies.

Indexed as

Biomedical ResearchDiabetes Mellitus, Type 1EpilepsyBibliometricsHumansbibliometricsdatabases, geneticdiabetes mellitus, Type 1epilepsygene expression profilinggenetic association studiesTSPO protein, human

Identifiers

PMID41098360
PMCPMC12520817

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.