ReviewBreathe (Sheffield, England)2025
Beyond genes: a clinician's guide to epigenetics.
Review in Breathe (Sheffield, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD.EMBO molecular medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic mechanisms control how and when our genes are switched on or off. They are altered by chronic environmental exposures, like cigarette smoke or air pollution, contributing to disease development. Excitingly, they can also be manipulated with the potential to target disease. Thus, epigenetic signalling provides a novel angle for understanding how chronic lung diseases develop and identifying novel biomarkers and therapeutic targets for respiratory diseases. This educational review is meant as a guide for clinicians and other lung researchers interested in epigenetic regulation. We introduce the main epigenetic modifications and the general cellular machinery that introduces and removes them. We provide selected examples of epigenetic dysregulation in response to environmental exposures and in chronic lung diseases. Finally, we discuss the promise of epigenetic biomarkers and therapies for clinical practice, including new precision medicine epigenetic editing approaches.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.