ArticleInternational journal of chronic obstructive pulmonary disease2025
Decreased Sputum Type-2 Gene Expression in COPD Current Smokers.
Article in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Chronic Obstructive Pulmonary Disease in Never-Smokers-A Distinct Entity Within the COPD Spectrum.Life (Basel, Switzerland) · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Higher blood eosinophil counts in COPD patients are associated with a greater response to inhaled corticosteroid (ICS) treatment, with type 2 (T2) inflammation being the target for ICS in COPD. Current smokers have reduced responses to ICS treatment. We have investigated whether current smoking modulates the levels of T2 mediators in the airways, thereby influencing ICS responsiveness. Methods: Induced sputum samples were collected from 73 COPD patients, including 41 ex-smokers. Twenty-six patients donated a second sputum sample, approximately 6 months after the initial sample. Sputum cell gene expressions of Results: Expression levels of all four genes significantly correlated with sputum eosinophil percentages. Conclusion: Sputum gene expression of
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