ArticleCureus2025
Lupus-Associated Autoimmune Hypophysitis: A Rare Case.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune hypophysitis (AH) is a rare inflammatory disorder of the pituitary gland, and its association with systemic lupus erythematosus (SLE) is extremely uncommon. We describe a 36-year-old man with newly diagnosed SLE who later developed fatigue, infertility, polyuria, and polydipsia. Hormonal evaluation revealed hypogonadotropic hypogonadism and low IGF-1. MRI showed pituitary stalk thickening and loss of the posterior pituitary bright spot, consistent with AH. Central diabetes insipidus (CDI) was confirmed by urine testing. The patient improved clinically after initiation of desmopressin and human chorionic gonadotropin (hCG) therapy. This case is notable because infertility and CDI were the initial manifestations of SLE-associated AH, representing an unusual clinical presentation that clinicians should be aware of.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.