ReviewCureus2025
Efficacy of Topical Corticosteroid Therapy in Chronic Rhinosinusitis Post-endoscopic Sinus Surgery: A Narrative Synthesis of Randomized Controlled Trials.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Impact of Rhinosinusitis and Its Treatment on Sleep-Disordered Breathing: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic rhinosinusitis (CRS) is a frequent inflammatory disorder that can markedly impair patients' quality of life. Endoscopic sinus surgery (ESS) remains the treatment of choice for refractory cases, but postoperative inflammation and adhesion formation are still major concerns. Corticosteroids are often prescribed to address these complications, although systemic administration carries the risk of adverse effects. This has led to growing interest in localized, topical corticosteroid therapies. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework and was prospectively registered in the International Prospective Register of Systematic Reviews (PROSPERO). Eligible studies included randomized controlled trials (RCTs) comparing topical corticosteroid interventions with standard postoperative care or placebo in CRS patients undergoing ESS. Searches were conducted in PubMed and Google Scholar up to July 2024. Data extraction and quality appraisal were independently performed by two reviewers, with disagreements resolved by a third reviewer. Of the 141 screened records, six RCTs comprising 530 participants met the inclusion criteria. Pooled analysis indicated that topical corticosteroids enhanced mucosal recovery, decreased adhesion (synechiae) rates, and reduced polyp recurrence. Drug-eluting stents and budesonide irrigation demonstrated the most notable benefits without significant systemic complications. Patient-reported improvements were consistently documented using the Sino-Nasal Outcome Test-22 (SNOT-22) and Lund-Kennedy scoring systems. Topical corticosteroid use following ESS offers clear benefits by promoting healing and minimizing complications, with limited systemic risks. Nevertheless, heterogeneity across trials highlights the need for further well-designed studies with standardized methodologies to strengthen the evidence base and guide routine clinical use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.