Evidence map›Paper›PMID 41098219›Full record

ReviewEJIFCC2025

The Role of Adiponectin in Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis.

Palani Selvam Mohanraj, Aniruddha Sen, Srinivas Nagaram, Vinoth Rajendran, Sundhar Mohandas, Neha Keshri, Akash Bansal, Abhimanyu Vasudeva, Anupriya Velu

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PubMed Full text at PMC
In one paragraph

Review in EJIFCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Palani Selvam MohanrajAll India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Aniruddha SenShri Gorakshnath Medical College Hospital and Research Centre, Gorakhpur, Uttar Pradesh, India.
Srinivas NagaramAll India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Vinoth RajendranMahayogi Gorakhnath University, Gorakhpur, Uttar Pradesh, India.
Sundhar MohandasMahayogi Gorakhnath University, Gorakhpur, Uttar Pradesh, India.
Neha KeshriAll India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Akash BansalAll India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Abhimanyu VasudevaAll India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
Anupriya VeluMahayogi Gorakhnath University, Gorakhpur, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diabetic peripheral neuropathy (DPN) is a prevalent microvascular consequence of diabetes with a complex etiology. Adiponectin, an adipokine with anti-inflammatory and neuroprotective properties, has been implicated in DPN, but its significance remains unclear due to conflicting findings. The objective of this systematic review is to assess the association between circulating adiponectin levels and the risk of DPN in individuals with diabetes. Methods: We did a systematic literature search in PubMed, Scopus, and CINAHL for studies investigating adiponectin levels in diabetes patients with and without DPN. A meta-analysis was done to evaluate the pooled mean difference in adiponectin levels between patients and controls. Study quality was rated using the Joanna Briggs Institute's critical appraisal tool. Results: The systematic review comprised 13 studies with 3,337 participants. Meta-analysis of 4 studies (920 participants) indicated no significant difference in adiponectin levels between DPN patients (n=418) and controls (n=502) (pooled mean difference 0.01, 95% CI: -0.24 to 0.26, p=0.94), with strong heterogeneity (I Conclusions: Our findings imply that circulating adiponectin levels are not linked with the risk of DPN in diabetes. However, the substantial heterogeneity among studies underscores the need for more well-designed prospective studies to explain the role of adiponectin in DPN etiology.

Indexed as

AdiponectinDiabetes MellitusDiabetic Peripheral NeuropathyDiagnostic markersMeta-AnalysisNeuropathic complicationsSystematic Review

Identifiers

PMID41098219
PMCPMC12519698

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