ArticleEJIFCC2025
Monoclonal Gammopathy Presenting with Pseudo Biclonal Pattern in Serum Protein Electrophoresis - An Interesting Perspective of Case Series.
Article in EJIFCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Monoclonal gammopathy (MG), arising from aberrant clonal proliferation of plasma cells, is diagnosed through the identification of an M-band via serum protein electrophoresis (SPEP), subsequently confirmed by immunofixation electrophoresis (IFE). The presence of two M-bands in SPEP is designated as double or biclonal gammopathy. Conversely, a pseudo-biclonal pattern is characterized by two M-bands on SPEP that resolve into a single immunoglobulin clone upon IFE. This case series delineates three instances of pseudo-biclonal patterns observed on SPEP in the absence of true biclonality. Methodology: Following ethical approval, a retrospective analysis was conducted on SPEP reports from Sri Ramachandra Medical College & Research Institute, Chennai, spanning 2022 to 2024. Capillary electrophoresis was employed for SPEP, followed by immunofixation. Results: Three cases exhibiting pseudo-biclonal patterns were identified. Case 1 involved a 73-year-old male with acute kidney injury, hypercalcemia, osteopenia, multiple fractures, and a reversed albumin/globulin ratio, where a biclonal pattern on SPEP resolved to IgA Lambda on IFE. Case 2 concerned a 57-year-old male with nodal marginal lymphoma evaluated for myeloma, whose SPEP biclonal pattern resolved to IgM Kappa with elevated polyclonal immunoglobulins on IFE. Case 3 was an 86-year-old female with acute-on-chronic kidney disease and urosepsis, where SPEP showed a biclonal pattern resolving to IgG Lambda and an additional Lambda isomer on IFE. Conclusion: This case series highlights pseudo-biclonal patterns stemming from monoclonal gammopathy, polyclonal elevations secondary to tumor lysis syndrome, and double gammopathy due to excess free light chains. The integration of SPEP with immunofixation, serum free light chain, and serum immunoglobulin assays enhances the detection of pseudo-biclonal patterns.
Indexed as
Identifiers
41098216PMC12519615What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.