ArticleFrontiers in human neuroscience2025
Enlarged perivascular spaces in the basal ganglia region are associated with white matter interstitial fluid content via deep medullary vein dysfunction.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Astrocyte-blood-brain barrier crosstalk in cerebral small vessel disease: linking barrier dysfunction to neurovascular failure.Frontiers in neurology · 2026Review
- Perivascular diffusion and white matter free water improve identification of cognitive impairment in cerebral small vessel disease.Frontiers in neurology · 2026Article
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Authors and funding
5 authors.
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Abstract
Objective: To investigate the effect of enlarged perivascular spaces in the basal ganglia (BG-EPVS) on interstitial fluid (ISF) content in white matter and to assess the mediating role of deep medullary vein (DMV) dysfunction in this relationship among patients with cerebral small vessel disease (CSVD). Methods: Magnetic resonance imaging and clinical data were collected from 166 patients with CSVD. EPVS score (0-4) was evaluated on T2-weighted images on the basis of the number of EPVS in a single slice. DMV score (0-18) was assigned on susceptibility-weighted imaging according to signal continuity and clarity. Free water (FW) values, representing ISF content in white matter, were derived from diffusion tensor imaging. Results: The mean age of the participants was 63.6 ± 11.1 years. The median score was as follows: BG-EPVS, 1 (IQR: 1-2); centrum semiovale EPVS (CSO-EPVS), 1 (IQR: 1-2); CSVD score, 1 (IQR: 0-2), and DMV, 4 (IQR: 1-11). The mean FW values were 0.25 ± 0.02. No significant correlation was observed between CSO-EPVS and FW ( Conclusion: Higher BG-EPVS score is significantly associated with increased ISF content in white matter, with DMV dysfunction serving as a key mediator of this association.
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