Evidence map›Paper›PMID 41098159›Full record

ReviewAvicenna journal of medicine2025

Association Between Steady-State Lactate Dehydrogenase Levels and Sickle Cell Complications: A Systematic Review.

Sagad O O Mohamed, Amged Mohammed, Fatima S K Salih, Hozifa A M Elgadal, Ayman A A Elsamany, Mohamed S K Salih, Huda M A Mustafa, Israa Elawad, Mona G A Ahmedkaroum, Safaa G A Saeed and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Avicenna journal of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sagad O O MohamedDepartment of pediatrics and child health, University of Khartoum, Khartoum, Sudan.ORCID 0000-0003-0597-2397
Amged MohammedMédecins Sans Frontières, Switzerland.
Fatima S K SalihDepartment of pediatrics and child health, University of Khartoum, Khartoum, Sudan.
Hozifa A M ElgadalDepartment of pediatrics and child health, University of Bahri, Sudan.
Ayman A A ElsamanyDepartment of Medicine, Ibri Regional Hospital, Oman.
Mohamed S K SalihDepartment of Medicine, Harlem Hospital Center, New York, United States.
Huda M A MustafaDepartment of Medicine, Cairo University, Egypt.
Israa ElawadDepartment of pediatrics, Sidra Medicine, Qatar.
Mona G A AhmedkaroumDepartment of pediatrics and child health, University of Khartoum, Khartoum, Sudan.
Safaa G A SaeedDepartment of Medicine, University of Medical Sciences and Technology, Sudan.
Rowa E A IbrahimDepartment of Medicine, University of Medical Sciences and Technology, Sudan.
Esraa A MohamedienDepartment of Medicine, University of Medical Sciences and Technology, Sudan.
Aya A H BabikerDepartment of Medicine, University of Medical Sciences and Technology, Sudan.
Esraa T SulimanDepartment of Medicine, AL-Neelain University, Sudan.
Eman O E MohamedDepartment of pediatrics and child health, University of Khartoum, Khartoum, Sudan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell disease (SCD) is a hereditary hemoglobin disorder characterized by vaso-occlusion and chronic hemolysis, leading to severe complications. Finding cost-effective and reliable biomarkers for predicting disease severity and identifying high-risk patients remains challenging, especially in resource-limited settings. This systematic review evaluates the association between lactate dehydrogenase (LDH) levels measured during clinical steady-state and various complications of SCD to assess its prognostic value. A systematic literature search, adhering to PRISMA guidelines, was conducted across Medline/PubMed, Web of Science, Embase, and ScienceDirect. Eligible studies included all observational studies examining the relationship between LDH levels and subsequent SCD complications. The statistical analyses were performed to calculate the pooled standardized mean difference (SMD) and its 95% confidence interval (CI). A total of 34 studies were included, highlighting significant associations between elevated LDH levels and various SCD-related complications. These included pulmonary arterial hypertension (SMD = 0.454, 95% CI: 0.032-0.875,

Indexed as

complicationslactate dehydrogenasesickle cell diseasesystematic review

Identifiers

PMID41098159
PMCPMC12520757

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.