ArticleHistology and histopathology2026
Early i-IFTA: Associated factors and impact on graft outcome.
Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Assessment of inflammation in scarred cortical parenchyma of kidney transplant (i-IFTA) is a criterion for chronic active T cell-mediated rejection (TCMR) and has mainly been explored in one-year protocol biopsies. We evaluated the factors, molecular profile, and one-year graft outcome associated with early i-IFTA. We included 101 kidney transplant biopsies performed within the first six months posttransplant (median=89 days), between 2009 and 2020. Interstitial inflammation Banff criteria were retrospectively re-evaluated, and diagnosis reclassification was performed according to the Banff 2022 classification. After re-evaluation, 85% of the biopsies presented no rejection, including 16% of biopsies from patients with delayed graft function, and 5% of biopsies with BK polyomavirus nephropathy. Eleven per cent (11%) of the biopsies presented histological TCMR. Delayed graft function was associated with i-IFTA severity (OR=2.78, 95% CI:1.01-7.68,
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