ArticleGlobal health action2025
Global, regional, and national burden of ischemic heart disease and ischemic stroke and their risk factors in youths and young adults aged 15-39 years (1990-2021): a comparative analysis of risk factors from global burden of disease study 2021.
Article in Global health action, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Association of high-sensitivity C-reactive protein and lipoprotein-associated phospholipase AFrontiers in physiology · 2026Article
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6 authors.
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Abstract
backgroundThere has been a growing trend of ischemic heart disease (IHD) and ischemic stroke (IS) affecting younger populations worldwide.
objectivesAssess and compare disease burden of IHD and IS in youth and young adults aged 15-39 from 1990 to 2021.
methodsUsing data from the Global Burden of Disease (GBD) 2021 study for individuals aged 15-39 years across 204 countries and territories, we estimated age-standardized incidence, prevalence, mortality rate, and disability-adjusted life years (DALYs) for IHD and IS. Temporal trends from 1990 to 2021 were evaluated using the average annual percentage change (AAPC). We estimated risk factor contributions by calculating the population attributable fractions (PAFs) of DALYs.
resultsIn 2021, the global age-standardized incidence rate (per 100,000 population) of IHD among youth and young adults was 36.86, approximately three times higher than that of IS (12.84). From 1990 to 2021, incidence and prevalence of IHD increased significantly (AAPC 0.25% and 0.20%). IS showed declining trends in all metrics (
conclusionsThis study highlights significant global disparities in the burden and trends of IHD and IS among young adults. More comprehensive and proactive interventions are urgently needed across all countries to mitigate the burden of IHD and IS on the young population.
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