Evidence map›Paper›PMID 41098026›Full record

ArticleArthritis care & research2026

Financial Distress and Its Determinants in Rheumatoid Arthritis.

Amber Brown Keebler, Yunju Im, Sofia Pedro, Ted R Mikuls, Edward S Peters, Kaleb Michaud

Abstract read
In one paragraph

Article in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Amber Brown KeeblerDivision of General Internal Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha.
Yunju ImDepartment of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha.
Sofia PedroFORWARD, The National Databank for Rheumatic Diseases, Wichita, Kansas.
Ted R MikulsDivision of Rheumatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha.ORCID 0000-0002-0897-2272
Edward S PetersDepartment of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha.
Kaleb MichaudFORWARD, The National Databank for Rheumatic Diseases, Wichita, Kansas.

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RIZZO, MATTHEW · 2016 to 2025
$42.8M
Department of Defense PR200793NIGMS NIH HHS U54 GM115458NIH HHS U54GM115458Rheumatology Research FoundationVA Merit I01-BX003635-05
6 · The paper itself

Abstract

objectiveTo quantify the degree of financial distress and identify its determinants in adults with rheumatoid arthritis (RA) given the frequent prolonged use of expensive disease-modifying therapies.

methodsWe identified adults enrolled in the FORWARD databank with either RA or noninflammatory musculoskeletal disease (NIMSKD) completing the Functional Assessment of Chronic Illness Therapy-Comprehensive Score for Financial Toxicity (FACIT-COST) questionnaire. In this cross-sectional study, FACIT-COST was analyzed as a continuous (higher score indicates less financial distress) and binary variable (presence of financial distress with threshold <26). Least Absolute Shrinkage and Selection Operator (LASSO) was applied to linear and logistic regression to select covariates for inclusion in multivariable models.

resultsParticipants with RA (n = 2,277) had lower FACIT-COST scores, indicating greater financial distress, than those with NIMSKD (n = 1,340) (mean of 30.2 ± SD 9.4 vs mean of 34.0 ± SD 8.4; unadjusted P < 0.001). Assessed as a binary outcome, financial distress was more frequent in participants with RA than participants with NIMSKD (29% vs 15%; unadjusted P < 0.001). Differences in financial distress by diagnosis persisted following multivariable adjustment. Among those with RA, determinants identified in multivariable models included depression (adjusted odds ratio 1.12; 95% confidence interval 1.09-1.16) and disease severity.

conclusionFinancial distress is prevalent in adults with RA and appears to be greatest in those with comorbidities, specifically depression, identifying a potential area for intervention. Notably, expensive biologic or targeted synthetic disease-modifying antirheumatic drugs were not associated with FACIT-COST scores.

Indexed as

Arthritis, RheumatoidCost of IllnessFinancial StressAdultAgedAntirheumatic AgentsCross-Sectional StudiesFemaleHumansMaleMiddle AgedSurveys and QuestionnairesAntirheumatic Agents

Identifiers

PMID41098026
PMCPMC13116011

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.