ArticleThe Journal of infectious diseases2026
Refined Transgenic Mouse Models Which Recapitulate the Natural Features of Chronic Wasting Disease With Rapid Prion Disease Onsets.
Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Distinct prion conformers from brain and peripheral tissues of gene-targeted mice produce convergent CWD strain properties.PLoS pathogens · 2026Article
- Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Prions are infectious, host encoded proteins which cause fatal neurodegenerative diseases of mammals. Seminal studies showed that overexpression of cervid prion protein (PrP) transgenes eliminated the transmission barrier to chronic wasting disease (CWD) prions in mice. Subsequent models which controlled expression from targeted alleles of the mouse PrP gene provided an improved framework for reproducing additional aspects of natural CWD. Here, we generated mice which combine the advantages of transgene overexpression with refinements afforded by gene targeting. Disease was characterized by accelerated onsets following peripheral or intracerebral challenges and by faithful recapitulation of native CWD strain properties including lymphotropic replication.
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Registered trials
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