Evidence map›Paper›PMID 41097999›Full record

ArticleASN neuro2025

Combined Treatment with Minocycline and an mGluR5 Antagonist Alters Resting EEG Spectral Power, but Not Sound-Evoked Responses, in a Mouse Model of Fragile X Syndrome.

M H Kassir, J W Lovelace, D K Binder, I E Ethell, K A Razak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M H KassirGraduate Neuroscience Program, University of California, Riverside, California, USA.
J W LovelaceDepartment of Psychology, University of California, Riverside, California, USA.
D K BinderGraduate Neuroscience Program, University of California, Riverside, California, USA.
I E EthellGraduate Neuroscience Program, University of California, Riverside, California, USA.
K A RazakGraduate Neuroscience Program, University of California, Riverside, California, USA.

Funding

Translational medicine and mechanistic studies of brain neurophysiology in Fragile X SyndromeU54HD104461 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI ERICKSON, CRAIG · 2020 to 2024
$8.1M
Synaptic, microcircuit and network mechanisms of cortical dysfunction in mouse models of Fragile X SyndromeP50HD118717 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Craig Erickson · 2025 to 2026
$5.7M
Molecular and cellular mechanisms of inhibitory synapse developmentR01NS129555 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Iryna M Ethell · 2024 to 2026
$1.4M
NICHD NIH HHS P50 HD118717NICHD NIH HHS U54 HD104461NINDS NIH HHS R01 NS129555
6 · The paper itself

Abstract

Fragile X Syndrome (FXS) is a leading genetic cause of intellectual disability and autism-like behaviors. Glutamatergic mGluR5 receptors and matrix metalloproteinase-9 (MMP-9) are therapeutic targets to treat FXS, but clinical trials targeting each of these pathways have not been successful. Here, we tested if the electroencephalography (EEG) phenotypes associated with FXS are reversed with a novel combination of treatments affecting the two pathways.

Indexed as

Evoked Potentials, AuditoryExcitatory Amino Acid AntagonistsFragile X SyndromeMinocyclineReceptor, Metabotropic Glutamate 5Acoustic StimulationAnimalsDisease Models, AnimalDrug Therapy, CombinationElectroencephalographyFragile X Messenger Ribonucleoprotein 1MaleMiceMice, Inbred C57BLMice, KnockoutExcitatory Amino Acid AntagonistsFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Grm5 protein, mouseMinocyclineReceptor, Metabotropic Glutamate 5Auditory hypersensitivityautism spectrum disorderscortical processingEEG phenotypesFragile X Syndromeglutamate receptorsmatrix metalloproteinase

Identifiers

PMID41097999
PMCPMC12533955

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.