ArticleBrain and behavior2025
Causal Relationship Between Anxiety Disorders and Cancers: A Bidirectional Two-Sample Mendelian Randomization Study.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Causal Relationship Between Anxiety Disorders and Cancers: A Bidirectional Two-Sample Mendelian Randomization Study.Brain and behavior · 2025Article
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3 authors.
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Abstract
backgroundAnxiety disorders are common psychiatric problems that often accompany cancer. The aim of this study was to investigate the potential causal relationship between anxiety disorders and common cancers.
methodsWe utilized publicly available summary statistics from large-scale genome-wide association studies, selecting genetic variant loci associated with anxiety disorders and common cancers as instrumental variables (IVs). These IVs underwent quality control according to three underlying assumptions. The results of the Mendelian randomization (MR) study were analyzed using the inverse variance weighted (IVW) method, along with MR-Egger regression and weighted median estimation (WME) methods, to evaluate the bidirectional causal relationship between anxiety disorders and common cancers. Additionally, we conducted heterogeneity and multivariate tests to validate the IVW results.
resultsThe bidirectional Mendelian randomization study revealed no positive causal relationship between anxiety disorders and common cancers. From a genetic perspective, the IVW analysis demonstrated that anxiety disorders are not associated with an increased risk of developing these common cancers (p > 0.05). Reverse MR analysis further revealed no significant causal relationship between common cancers and anxiety disorders (p > 0.05).
conclusionsMR analysis results demonstrated no significant causal relationship between anxiety disorders and common cancers.
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