ArticleBrain and behavior2025
Confirmation of the Enhancement Effect of ANCE Treatment on Functional Recovery of Manual Dexterity From Primary Motor Cortex (M1) Lesion in Adult Macaque Monkeys.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Re-Examination and Extension of Manual Dexterity Behavioral Data in M1 Lesioned Adult Macaque Monkeys: A Survey of Therapies Induced Enhancement of Functional Recovery.Neuroscience insights · 2026Article
- Is there a correlation between functional recovery of manual dexterity after motor cortex lesion and initial motor learning slope in the intact state?Frontiers in systems neuroscience · 2026Article
- Confirmation of the Enhancement Effect of ANCE Treatment on Functional Recovery of Manual Dexterity From Primary Motor Cortex (M1) Lesion in Adult Macaque Monkeys.Brain and behavior · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
introductionA pilot study provided preliminary evidence indicating that peri-lesional adult autologous neural cell ecosystem transplantation (so-called ANCE) can enhance the functional recovery of manual dexterity in macaque monkeys following a unilateral lesion of the hand representation in the primary motor cortex (M1). As compared to five untreated control animals subjected to M1 lesions, the improvement of functional recovery was observed in our pilot study in two ANCE-treated monkeys (also M1 lesioned). To strengthen these promising preliminary results, the present study aimed at introducing two additional ANCE monkeys, as well as one new control monkey, all subjected to M1 lesion.
methodsManual dexterity was assessed based on the modified Brinkman board task, performed with the contralesional hand to retrieve small food pellets from slots using the precision grip (opposition of thumb and index finger).
resultsAs with the two pilot ANCE-treated monkeys, the two new ANCE-treated monkeys exhibited a rebound of functional recovery (a second plateau) associated to the treatment (after approximately 2-3 months delay post-treatment), following a first plateau of spontaneous recovery. In contrast, all control monkeys (n = 6) exhibited a single plateau of functional recovery.
conclusionThe present study confirms that ANCE treatment significantly improves functional recovery from motor cortex lesions in adult macaques, with performance gains ranging from 20% to 40%. These findings support a possible future initiative to initiate clinical trials based on ANCE therapy.
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